Kyle Juszczyk has played a sizable role on offense for the Niners so far this season and head coach Kyle Shanahan said after the game that the initial belief was that he suffered a sprain. Juszczyk will go for an MRI on Tuesday.

Tom Pelissero is reporting Juszczyk has an MCL injury which could sideline him a month or so.

"There seems to be a connection between Jimmy Garoppolo and Trent Taylor," fullback Kyle Juszczyk said. "And he just seems to be moving at another speed and just has an incredible feel for space on the field. Many times, it's just him and Jimmy just kind of improvising."

Don't be surprised if he leads the team in targets and receptions, according to beat writer Nick Wagoner.

Taylor suffered a Jones fracture in his foot last week that will keep him out the rest of the preseason, but the Niners are hopeful he will be back for Week 1. When he does return, the hope is he will pick up where he left off after a training camp that left teammates and coaches raving about his bounce-back from an injury-plagued 2018 season. We have him down the team's depth chart, but he's a name to keep an eye on.

49ers Matt Breida sustained a mid- to high-ankle sprain.

Related players: Alfred Morris, Kyle Juszczyk

The tweet said he'll undergo an MRI on Monday to see how much damage was done. Maiocco said Breida may not be able to go Week 6 which would leave Morris as the main ball carrier. And, it's possible he misses a couple of weeks. The 9ers want to give it time to heal and not be something that bothers him throughout the rest of the season. Juszczyk had six catches for 75 yards in the loss, so he could have some value in deeper formats.

The 49ers gave running back Jerick McKinnon a four-year, $30 million contract in free agency to be their multidimensional weapon coming out of the backfield. So, expect the 49ers to be more than a bit anxious for the results of an MRI that McKinnon will undergo after he suffered a right knee injury during practice on Sunday.

Related players: Matt Breida, Kyle Juszczyk

According to reporters in attendance, McKinnon went down clutching his knee during team drills. But after the training staff tended to him, he appeared to be OK considering he remained present at practice and stuck around afterwards to sign autographs.