49ers head coach Kyle Shanahan announced Wednesday that tight end George Kittle will not play Sunday against the Cardinals.

Kittle is clearly a good bit away from recovering with him already being ruled out Wednesday. The 49ers offense was certainly not as effective, as expected, against the Seahawks on Monday night and at least played a part in then suffering their first loss of the season. The 49ers really need players like Dante Pettis and Deebo Samuel to step up win Kittle out and Emmanuel Sanders suffering an injury Monday as well.

49ers Shanahan on George Kittle and Robbie Gould, says hopeful for both, similar to last week

Kittle watched from suite tower than sideline because they didn't want him to stand for 3 1/2 hours straight the tweet said. With Emmanuel Sanders also a question mark, the 49ers desperately need at least one of the two back for Week 11 against the Cardinals.

49ers TE George Kittle (knee, ankle) is listed as doubtful for Monday night against the Seahawks.

The prevailing thought had been that Kittle's chances are playing were lessening by the day and this all but assures Kittle will not be a part of what will be a huge battle in the NFC West Monday night. This is certainly a big loss for the 49ers. Expect a mix of Ross Dwelley and Levine Toilolo to try and fill the void left by Kittle. For what it's worth, Maiocco reports head coach Kyle Shanahan is "leaving hope" that Kittle will play, but "if things don't change, he will not play."

49ers TE George Kittle is not practicing Thursday with ankle and knee injuries.

Head coach Kyle Shanahan said the team will not know Kittle's status until the end of the week. The 49ers play on Monday night, so their final injury report won't come out until Saturday. Kittle would be a big loss for the 49ers going into a huge NFC West showdown with the Seahawks. You might want to check into backup options now just in case Kittle can't go so you're prepared, though the Monday night kickoff does throw a minor wrench into those plans. Check back Friday and Saturday on Kittle's progress.

Tight end George Kittle was not on the practice field, as the 49ers held a short practice Tuesday to begin preparations to face the Seattle Seahawks in Week 10.

Kittle injured to his left knee on the 49ers’ first offensive play in the team’s 28-25 victory over the Arizona Cardinals. Kittle returned to the game after taking an inadvertent helmet to his knee as he was blocking on a running play.

The 49ers did not provide an injury update Tuesday, but coach Kyle Shanahan suggested Friday that Kittle would at least be limited this week. The team said they are hoping Kittle plays this week and don't believe it's a long term injury.

49ers TE George Kittle says his knee is good after suffering the injury in Thursday's win over the Cardinals.

Rapoport says it sounds like the MRI done on Kittle's knee Friday confirmed just a minor knee injury for Kittle. There is optimism he will be available for Week 10 against the Seahawks. Working in Kittle's favor is he effectively has four extra days to heal, as the 49ers are coming off a Thursday game and their next game is on a Monday night. Kittle caught six passes for 79 yards and a touchdown in the 28-25 win over Arizona.