Wide receiver Deebo Samuel and running back Jeff Wilson Jr., both of whom played major roles in Sunday's 33-6 win against the New England Patriots, are expected to miss extended time, according to coach Kyle Shanahan.

Related players: Kendrick Bourne, Jerick McKinnon, JaMycal Hasty

Samuel is dealing with a left hamstring strain and will "most likely" miss this week's game at the Seattle Seahawks and next week's home contest against the Green Bay Packers, according to Shanahan. Wilson is the latest 49er to suffer a high left ankle sprain and is expected to go on injured reserve this week, which means he will have to miss at least the next three games, the story said. As we reported just a bit ago, Bourne looks like he'll take over for Samuel while McKinnon could jump back into a bigger role at RB. The 49ers said they purposely cut back on McKinnon's workload this past week (surprise fantasy owners) but it should mean he gets a bigger role this week. However, the rookie Hasty has looked good and could take some of the workload at RB.

Kyle Shanahan said that the 49ers were planning to rest Jerick McKinnon all along.

Related players: Jeff Wilson, JaMycal Hasty, Tevin Coleman

Would have been nice to know... McKinnon didn't get work until Wilson suffered what looked like a serious injury to his ankle. The reason the 9ers gave was it was due to his heavy workload in some games earlier this season. With Wilson's status up in the air, at best, for Week 8, McKinnon should be back in the picture along with the rookie Hasty. With Coleman on the verge of coming back, he could also enter the picture to make the backfield situation even more cloudy.

The 49ers believe RB Jeff Wilson suffered a high ankle sprain during Sunday's win over the Patriots.

A very unfortunate way for Wilson's fine day to end after he rushed for 112 yards and three touchdowns, helping San Francisco dominate New England, 33-6. This comes just a few days after the team placed Raheem Mostert on injured reserve as well. JaMycal Hasty ended up with some of the cleanup work, finishing with nine carries for 57 yards, while Jerick McKinnon saw three carries for -1 yard. The 49ers running game continues to be a major weekly puzzle heading into a big divisional showdown with the Seahawks in Week 8.

49ers RB Jeff Wilson was carted off the field with an injury after scoring his third touchdown against the Patriots.

Wilson was having himself a day. He rushed for 112 yards on 17 carries and three touchdowns, but suffered the injury during the third touchdown run. The 49ers are already banged up at the running back position. Raheem Mostert was placed on injured reserve this week. The 49ers likely will turn back to Jerick McKinnon and JaMycal Hasty in the backfield.

49ers coach Kyle Shanahan said RB Raheem Mostert has a high sprained left ankle. He's expected to miss time, will "most likely" go on IR.

Related players: Jeff Wilson, Jerick McKinnon, JaMycal Hasty

Mostert will miss at least three weeks if placed on IR. Tevin Coleman is still out which will leave Wilson, McKinnon and Hasty to take over. McKinnon has struggled as of late so it could be a hot-hand situation has Hasty looks to make a name for himself.

49ers RB Jeff Wilson Jr. is questionable for Sunday's game against the Los Angeles Rams, according to Matt Maiocco of NBC Sports Bay Area.

Wilson's role faded with the return of Raheem Mostert. He still remains a red zone threat when healthy.