Seattle quarterback Russell Wilson suffered a left knee injury in the third quarter with the Seahawks leading big.

Wilson was pulled down awkwardly while being sacked by San Francisco's Eli Harold with 10 minutes to go in the third quarter. Harold was flagged for a horse collar tackle on the play as he fell on Wilson's lower leg. Wilson stayed down for a few moments before hoping up and limping around. He missed one play on that series - the first missed play of his career due to injury - but returned to throw one more pass, a 10-yard completion to Doug Baldwin.

Wilson was on the Seattle bench for its next offensive possession having a brace put on his left knee after a San Francisco turnover led to a quick change of possession. Trevone Boykin took over and Steven Hauschka's third field goal gave Seattle a 30-3 lead.

The knee injury comes on top of Wilson playing the last two weeks after suffering a sprained right ankle in the opener against Miami. Wilson was said to have more mobility coming into this week with the ankle, but the knee injury at least puts in question his status for the Seahawks next game.

Seahawks quarterback Russell Wilson spoke optimistically following Sunday’s 9-3 loss to the Los Angeles Rams of being healthier for next Sunday’s game against the 49ers at CenturyLink Field.

Monday, during his weekly radio show on ESPN 710 Seattle, Seahawks coach Pete Carroll said Wilson had a good first step in that regard by coming out of the Rams’ game “a little bit sore” but without any re-injury adding “he was okay coming out.”

Carroll also said it’s unclear when Wilson will be 100 percent recovered from the sprained right ankle. Carroll said the rehab plan is similar for Wilson this week and that he will likely again do a little less in practice.

Seahawks coach Pete Carroll, during his weekly interview on 710 ESPN, said that quarterback Russell Wilson’s sprained ankle was “nothing very serious.”

“He’s all fine there,” Carroll said, via Bob Condotta of the Seattle Times. “A little bit of swelling but he’ll make it through.”

Carroll suggested that Wilson might miss some practice time, but indicated that he wouldn’t miss a game. Trevone Boykin is the only other QB on the team's roster. As we pointed out earlier Monday in a story from ESPN, even if Wilson plays the Seahawks may have to tweak their playcalling a bit as Wilson is not expected to be as mobile as usual.

The Seahawks admitted they had to call the game differently after the QB Russell Wilson injury.

"We looked after him a little bit," HC Pete Carroll said. "We weren't sure what he could do, and we didn't want to tax him too much. We kept him in the pocket more than normal, just to make sure that we didn't force him to go."

Wilson said in the story he's comfortable playing in the pocket, but with the recent news his ankle injury is significant, his status for Week 2 is now in question. If he plays, he likely won't be 100-percent and the Seahawks could be forced to run more and rely more on Wilson's arm instead of his athleticism.

Seattle Seahawks quarterback Russell Wilson has a "significant" right ankle injury and his availability to play in Sunday's game against the Los Angeles Rams has been put into question, reports NFL.com's Ian Rapoport.

Wilson was injured in the third quarter of Seattle's 12–10 victory over the Miami Dolphins when he was sacked by Dolphins defensive tackle Ndamukong Suh. Wilson did not miss any snaps in the game.

After the game Wilson said he would be fine with treatment and expected to play Week 2, but as can be typical with ankle injuries, it likely swelled up after the tape came off. Trevone Boykin is behind Wilson in the pecking order and he obviously downgrades any Seattle passing options. Owners may want to start looking at a backup plan for Week 2.

I'm told Russell Wilson is right now getting a precautionary x-ray on his right ankle.

Wilson suffered the injury in the first half but didn't miss any time. Because of that, we can only assume, as of now, he should be OK for Week 2, but we'll continue to monitor the situation. Obviously this kind of injury can affect Russell's mobility.