Thursday Night Football: Giants at 49ers Odds, Stats, More

Sep 21, 2023

Jayne Kamin-Oncea / USA Today Sports

The New York Giants visit the San Francisco 49ers for a battle on Thursday Night Football at 8:15 pm ET on Prime Video. Here's what you need to know about the game including odds, injuries, stats, sportsbook promo codes, and more.

New York Giants at San Francisco 49ers Matchup

The 49ers enter the game at 2-0 after a 30-7 win over the Pittsburgh Steelers and a 30-23 win over the Los Angeles Rams. The Giants were crushed 40-0 in week 1 vs. the Cowboys and needed a 2nd half comeback to beat the Cardinals 31-28 in week 2.

Eyes will be on running back Christian McCaffrey as he leads the NFL with 268 rush yards so far this season. Both teams are in the middle of the pack in terms of total yards given up on defense with the 49ers giving up 312.5 yards per game so far and the Giants are at 322 yards per game.

Giants at 49ers Injury Report

Star running back Saquon Barkley is out for the Giants with an ankle injury which is a huge hit to New York. Here's a look at the injury report for the game.

Giants
- RB Saquon Barkley - Out (Ankle)
- OT Andrew Thomas - Out (Hamstring)
- LB Micah McFadden - Questionable (Neck)
- G Ben Bredeson - Out (Concussion)
- LB Azeez Ojulari - Out (Hamstring)
- WR Wan'Dale Robinson - Questionable (Knee)
49ers
- WR Brandon Aiyuk - Questionable (Shoulder)

Giants at 49ers Odds and Props

If you are interested in betting on the game. Here are the latest odds on the game.

Moneyline: Giants (+410) at 49ers (-550)
Point Spread: Giants (+10.5) at 49ers (-10.5)
Total: O/U 44 points

There are plenty of popular betting markets including props for Thursday Night Football. A popular pro is first TD scorer. Here are the latest odds for first TD scorer on Thursday Night Football for Giants at 49ers.

If you are looking to place a wager on the game as a new bettor, check out the best sportsbook promo codes at the bottom of the page or by visiting or sportsbook bonuses page.

More NFL Week 3 Matchups

There is plenty of great NFL action for week 3 of the season. We've got Giants at 49ers tonight and a full slate for Sunday. Here are the upcoming games for the weekend.

Sunday at 1 pm ET
- Broncos at Dolphins
- Falcons at Lions
- Colts at Ravens
- Texans at Jaguars
- Bills at Commanders
- Patriots at Jets
- Saints at Packers
- Titans at Browns
- Chargers at Vikings
Sunday at 4:05 pm ET
- Panthers at Seahawks (-6)
Sunday at 4:25 pm ET
- Cowboys (-12) at Cardinals
- Bears at Chiefs (-12.5)
Sunday at 8:20 pm ET
- Steelers at Raiders (-2.5)
Monday at 7:15 and 8:15 pm ET
- Eagles (-5) at Bucs
- Rams at Bengals (-2)

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bet365 Promo Code

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DraftKings Promo Code

DraftKings Sportsbook has two promotions wrapped in one. You get $200 in bonus bets after placing a $5 wager and you get up to $150 in No Sweat Bets for NFL games. You can place up to three $50 bets on NFL games. If they lose, you get your money back in bonus bets.

BetMGM Promo Code

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Caesars Promo Code

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