Week 6 vs. Arizona Cardinals
It's hard to imagine Ezekiel Elliott taking on an even larger workload, but with Dak Prescott going down for the season, Elliott will be more important than ever for the Cowboys as they handle the fallout of losing their franchise quarterback for the season. The entire Cowboys offense will suffer from losing Prescott, but Andy Dalton is one of the better backup quarterbacks in the league and should be able to keep the offense afloat alongside Elliott. Elliott could even offset a hit in touchdown opportunities with additional volume if Dallas leans more on the running game with Dalton under center. Losing Prescott does present some concerns for Elliott's fantasy profile, particularly if Dalton looks Elliott's way less in the passing game. Prescott gave Elliott 32 targets over five games, which made Elliott immune to game script concerns even as the Dallas defense gave up tons of points. Dalton's effect on the Dallas offense will be one of the biggest storylines of Week 6, but Elliott should still be able to muster RB1 production without his starting quarterback.