Fantasy Upside
Karlos Williams appeared to be far down in the depth chart at the beginning of training camp, but the rookie now has a great opportunity in front of him. Fred Jackson was released and Anthony Dixon is hurt. So, Williams becomes the primary backup to LeSean McCoy by default.
Fantasy Downside
We don't know what we will get from Williams at the professional level, but we do know he will now get some touches. He could lose those touches to Dixon when he comes back or even to veteran Bryce Brown, who currently sits behind Williams on the depth chart going into the season.
Bottom Line
Williams should not be a player you draft, but you can pick him up for depth once you see how the Bills use him. My guess is he might get around give touches a game, but if he gets more, he is someone you should to add to your fantasy roster.