Fantasy Upside
Mike Gillislee was able to get some playing time in his first season with Buffalo due to injuries on the running back depth chart. He showed enough to remain in the Bills plan and with Karlos Williams suspended for four games, he moves in to LeSean McCoy's backup role to start the 2016 season. He did average 5.7 yards per carry.
Fantasy Downside
Most likely when Williams returns Week 5,Gillislee's role will be diminshed so his draft value is for four games. It's potluck after that.
2016 Bottom Line
Gillislee has some value for those first four games, but after that, it will probably be Karlos Williams as the backup again. Drafting Gillislee, but having him ready off the waiver wire is a good idea as he has some value in deep leagues for the first four games.