Squirrel Patrol's Week 7 NFL Main Slate DFS GPP Picks

Oct 23, 2026

IMAGN IMAGES via Reuters Connect

Week 7 brings a 10-game main slate on Sunday, kicking off at 1 PM ET, with DraftKings featuring multiple Millionaire Maker contests and FanDuel offering a contest with a $1 million total prize pool. GB/DET carries the highest total on the slate at 55.5, with the Lions favored by 3.5, and it is one of three games in the late window, with a 4:25 PM ET kickoff. SF/ATL is next at 50.5, with the 49ers favored by 2.5, followed by LAR/LV at 48.5 (Rams -3.5) and CIN/BAL at 46.0 (Bengals -3.0). CLE/TEN has the lowest total on the slate at 36.5. The Lions carry the highest implied team total at 29.5, with the 49ers and Texans (26.5) and the Rams and Packers (26.0) behind them, and Houston is the biggest favorite on the slate at 10.5 points over the Giants.

Injuries are shaping the slate again. Lamar Jackson (ankle) has been ruled out, and Tyler Huntley will make his third straight start for Baltimore. Breece Hall (quad) is questionable and reportedly unlikely to play, and I'm writing this assuming he is out. Puka Nacua (calf) is a game-time decision after missing Friday's practice, and I'm assuming he plays. Matthew Golden (shoulder) and Christian Watson (ankle) are both questionable after limited practices all week, and I'm assuming both play. Baker Mayfield (thumb) is listed as questionable but is expected to return after missing three games, and the Buccaneers have ruled out Emeka Egbuka (concussion/foot). David Montgomery (groin) missed Week 6 for Houston and did not practice Wednesday or Thursday. Josh Jacobs came off the Commissioner's Exempt List this week, and Matt LaFleur expects him to make his season debut for a Packers offense that has run for the fewest yards in the league.

Let's break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards this Sunday.