San Francisco 49ers
OUT
K Joe Nedney (right knee), T Joe Staley (fibula)
QUESTIONABLE
LB Navorro Bowman (hamstring), LB Takeo Spikes (hand), LB Patrick Willis (hand)
PROBABLE
TE Nate Byham (shoulder), G Mike Iupati (shoulder), RB Brian Westbrook (not injury related), RB DeShawn Wynn (ankle)
San Diego Chargers
OUT
WR Patrick Crayton (wrist), LB Larry English (foot)
DOUBTFUL
TE Antonio Gates (toe, foot)
QUESTIONABLE
WR Malcom Floyd (hamstring), LB Brandon Siler (ribs), G Louis Vasquez (neck), S Pat Watkins (knee)
PROBABLE
DE Jacques Cesaire (knee), DT Antonio Garay (ankle), T Marcus McNeill (knee), WR Legedu Naanee (hamstring)
For the 49ers, Jeff Reed will again handle kicking duties.
For the Chargers, look for Randy McMichael to start at TE with Gates doubtful. Floyd will be a game-time decision, although he sounds likely to play. Vincent Jackson is the healthiest Chargers wideout.