Quarterback Alex Smith threw for 126 yards and an inter...

Quarterback Alex Smith threw for 126 yards and an interception in San Francisco coach Jim Harbaugh’s home debut, getting showered with a mix of boos and cheers as San Francisco beat Oakland 17-3.

Smith was 8 for 13 and came up empty in the end zone again. He had a pass picked off by defensive end Matt Shaugnessy in the second quarter and could only lead the 49ers (1-1) to a field goal in one half of play.

The 2005 No. 1 overall pick at least left healthy. Oakland starting quarterback Jason Campbell didn’t return after taking a couple of blows on a scramble play in the second quarter.

The Raiders are 0-2.

Fantasy Impact: 

It's no great surprise to see Smith struggle once again. Although Vernon Davis and Frank Gore should be fine regardless, it's going to be a long year for Braylon Edwards and Michael Crabtree until Colin Kaepernick takes over. At least there would be hope for better days with Kaepernick.

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