Lewis lasted three snaps in his season debut before re-aggravating a left calf strain.
Lewis originally injured the calf during warm-ups prior to the second preseason game against the New York Jets Aug. 17. He suffered a setback during practice in the week leading up to the regular-season opener against Kansas City.
Lewis had missed three games in his entire career with the Jaguars and now will be out indefinitely.
Fantasy Impact:
Clay Harbor is next up at the position but with Blaine Gabbert at QB it seems like downgrades are necessary for all Jacksonville receivers.