Week 1 at Jacksonville Jaguars
Patrick Mahomes amazed everyone last season, throwing for 50 touchdowns (rushing for two more) on his way to an MVP award. Nothing major has changed on offense from last season to this year, unless you count the absence of Kareem Hunt, so Mahomes should be in line for another huge year. He may not replicate what he did in 2018, but it wouldn't be too surprising to see him come close.
He gets a tough first matchup against the Jaguars, who allowed the second-fewest passing yards and passing touchdowns in the league last season. Mahomes had his worst game of the season against Jacksonville last year, finishing with no passing touchdowns and two interceptions. But he didn't exactly struggle, as he did have 313 yards in the contest. Even though it's not a great matchup, Mahomes is still a must-start QB1 choice.