It's hard to blame the Bills from straying away from RB C.J. Spiller (12-of-69 snaps). Spiller was stopped for a 3-yard loss on the first play of the game, an avoidable play where Spiller ran away from the line of scrimmage at one point trying to elude a defender.
Spiller ran only twice after his late first-half fumble, although part of that was the scoreboard; the Bills were trailing more as the game progressed.
Fantasy Impact:
The team chose to put the ball in the hands of Fred Jackson who came in with an ankle injury. Jackson played on 52-of-69 snaps and recorded a TD. Spiller's workload continues to dwindle and he's becoming less and less of a usable fantasy option.