Commanders RB Austin Ekeler leaves with concussion

And to top it off, 49ers RB Christian McCaffrey is seeing a specialist in Germany regarding his Achilles tendinitis.

Related players: Jordan Mason, Isaac Guerendo, Patrick Taylor

This doesn't sound good for CMC. Now owners can't help but wonder if McCaffrey will be back after missing his four games on IR. Mason has filled in well, gaining 5.2 yards per attempt with two touchdowns on the season. But at this point, with CMC seemingly a huge question mark, it may be time to pick up players like Guerendo and Taylor. Guerendo was the only other back to get carries in Week 3, running five times for 19 yards.

There won’t be any suspense about wide receiver Cooper Kupp’s status this week.

Rams head coach Sean McVay told reporters on Monday that Kupp has been ruled out for the team’s Week 4 game against the Bears.

Related players: Tutu Atwell, Demarcus Robinson, Jordan Whittington, and Tyler Johnson

Kupp injured his ankle in Week 2. The story said the early decision to rule him out suggests he’ll be off the practice field again this week, but the team did not put Kupp on injured reserve so it would seem they expect him to play by Week 7 — they have a bye in Week Six — at the latest. Atwell led the way with a 4-93-0 line with Robinson going for 1-32-0. Whittington added a line of 3-28-0 and Johnson had 3-20-0. With Puka Nacua also out for at least two more weeks, the Rams WR situation seems a bit tricky for fantasy owners.

Arizona Cardinals HC Jonathan Gannon says TE Trey McBride is in concussion protocol.

Related players: Elijah Higgins, Tip Reiman, Travis Vokolek

Gannon said the team will have to see how McBride goes throughout the week, and fantasy owners will need to monitor his progress as well. We list Higgins as next up on the depth chart, but Reiman was a fairly highly-rated rookie at the position for those who remember his name from dynasty leagues.