Shanahan said Isaac Guerendo (hamstring) was trending well and is expected to practice this week.

Related players: Patrick Taylor, Deebo Samuel

The Niners play on Monday night at home against the Lions. So those waiting on Guerendo may want to have a backup plan. Hopefully owners will get more information about his status well before that. He should be in line for a big workload, if he plays, just given his draft capital and past usage as the team's now RB1. Samuel would likely get some carries as well.

49ers injury report vs. Dolphins:
Out
RB Isaac Guerendo (foot, hamstring)
OT Trent Williams (ankle)
Questionable
DE Nick Bosa (hip, oblique)
LB Dre Greenlaw (Achilles, knee)
DE Robert Beal (ankle)
(Approximately, 70% of the players the 49ers listed as questionable have played.)

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out, but the others should just be on WW watch for now.

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source.

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

Sheesh. We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out.

In Week 15, the red and gold have defensive lineman Nick Bosa and linebacker Dre Greenlaw active and ready for the team's second meeting with their NFC West rival, the Los Angeles Rams.

On the other side of the ball, the 49ers will have rookie running back Isaac Guerendo available against the Rams. He was listed as questionable on Wednesday on account of a foot sprain but was given the green light to play ahead of "Thursday Night Football."

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We do expect Guerendo to handle the majority workload for TNF, but you do have to wonder if he gets the same type of workload he would have, had he avoided the injury report all week. Consider him closer to an RB3 than a locked-in RB2 he otherwise would have been.

San Francisco 49ers running back Isaac Guerendo plans to play Thursday night against the Los Angeles Rams despite his sprained foot, sources told ESPN's Adam Schefter.

Guerendo, who is listed as questionable, insists he "feels good," sources said.

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette *if* Guerendo is forced out, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

Otherwise, consider the fourth-round rookie a fantasy RB2.

— The 49ers ruled out LT Trent Williams (ankle) and S Malik Mustapha (chest), but RB Isaac Guerendo (foot) is questionable. So is Dre Greenlaw, who was full today.
— The Rams ruled out TE Tyler Higbee (knee) and Cobie Durant (chest).

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

49ers head coach Kyle Shanahan shared his team’s pre-practice injury report at a Tuesday press conference and it was the same as Monday’s estimated one, so several key players are on the sideline ahead of Thursday’s game against the Rams.

Among them was RB Isaac Guerendo.

Related players: Patrick Taylor, Israel Abanikanda

Guerendo had a great game in Week 14, but left with a sprained foot. Guerendo said afterward he felt great and it was just precautionary. However, we know by now we can't always trust when a player talks about his status for the following week. The DNPs for both Monday and Tuesday are not a great sign for Guerendo's chances to play in Week 15, which is a short week against the Rams on Thursday Night Football. Guerendo's practice status for Wednesday will hopefully will give us a better idea. Taylor would likely be next up for the 49ers if Guerendo can't go.

Isaac Guerendo doesn't seem concerned about the foot sprain he suffered today.

Related players: Patrick Taylor, Israel Abanikanda

Guerendo was having a great fantasy day and was the team's clear RB1 against the Bears before leaving with a foot sprain. There are a couple of reports out there, including this one which comes from the Mercury News, saying Guerendo leaving was just precautionary, and that he "feels great." Other reports don't necessarily mention that. Hopefully we'll learn more today. What complicates this injury is the Niners take on the Rams on Thursday night, so it's a short week. We'll at least learn more as the practice week goes on. If Guerendo can 't go, Taylor is up next with newly-signed Abanikanda after that.

The 49ers were down to one healthy running back on their active roster, so they added another one off the waiver wire on Tuesday.

The NFL’s daily transaction report shows that they have claimed Israel Abanikanda off of waivers from the Jets. Abanikanda was let go on Monday when the Jets signed running back/kick returner Kene Nwangwu to the 53-man roster.

Christian McCaffrey was officially moved to injured reserve in a corresponding move.

Related players: Isaac Guerendo, Patrick Taylor, Ke'Shawn Vaughn

Guerendo is expected to take over the team's RB1 role with Christian McCaffrey and Jordan Mason both heading to IR. Abanikanda should be a familiar name to those in dynasty circles. He was a 2023 fifth-round pick but at the time was buried on the depth chart with the Jets, and he never earned much of a role on offense and didn’t play in the regular season this year, the story said. He appeared in six games as a rookie and ran 22 times for 70 yards while catching seven passes for 43 yards, the story added. The team also signed Vaughn to their practice squad.

Per Kyle Shanahan, 49ers RB Christian McCaffrey us going back on IR with his PCL injury.

Related players: Isaac Guerendo, Deebo Samuel, Jordan Mason

It’s a 6 week recovery time for CMC, the post went on to say. It's possible he could return if the Niners make a long playoff run, but for this fantasy season, McCaffrey is done. Sandler, in a separate post, mentioned that Mason will also go on IR with a high ankle sprain, leaving Guerendo as the assumed RB1. The Niners will have to make a move to bring in more running backs, but the team did trade up in the fourth round to pick Guerendo, so it's possible they give him a legit chance the rest of the season. He should be a popular pickup off the wire this week.