Brandon Aiyuk (shoulder) will be, as expected, a game-time decision for 49ers-Giants on TNF, per John Lynch on KNBR

Related Players: Deebo Samuel, Jauan Jennings, Ronnie Bell

The 49ers rarely have their "Big Four" all on the field simultaneously, which is a shame because it's such a fun offense to watch when it's rolling. We can expect a slight uptick in target share for both George Kittle and Deebo Samuel, while it's also likely Christian McCaffrey will get a little more action as a receiver. Though Jauan Jennings had a couple of big plays in the team's Week 2 victory, it's not enough to consider him in fantasy outside of DFS Showdown slates.

Update from the 49ers: Deebo Samuel has a MCL sprain and an ankle sprain and he's expected to return at some point during the regular season.

Related Players: Jordan Mason, Brandon Aiyuk, George Kittle, Jauan Jennings, Ray-Ray McCloud

This is a bummer for the team and fantasy purposes, as this impacts the playoff implications for both facets. If you don't have an IR spot, it may be a waste of a spot for Deebo if he isn't going to return before Week 17.

Deebo Samuel (hamstring) was limited for the second straight practice

Related Players: Brandon Aiyuk, George Kittle, Jauan Jennings

If Deebo were to miss, it's possible that there's a little more touchdown equity for the receiving corps as well as Christian McCaffrey and Elijah Mitchell. Samuel hasn't been used as often in the run game as he was in 2021, but he does have two rushing TDs on the season.

FULL 49ers' injury summary:

No practice:
Arik Armstead (foot/ankle)
Samson Ebukam (quad/Achilles)

Limited:
Jason Verrett (knee)
Dre Greenlaw (calf)

Full:
Deebo Samuel
Jauan Jennings
Kyle Juszczyk
Colton McKivitz*
Azeez Al-Shaair*
Elijah Mitchell*

*No official designation (IR)

Good news for Deebo owners. Samuel missed Week 8 with a hamstring injury which led up to the team's bye in Week 9. The extra rest seems to have helped, and it appears Samuel should be good to go in Week 10.

Not practicing today for the 49ers:
* Deebo Samuel (hamstring)
* Kyle Juszczyk (finger)
* Dre Greenlaw (calf)
* Arik Armstead (foot/ankle)
* Jauan Jennings (hamstring)
* Samson Ebukam (Achilles tendinitis)

The Niners have a bye in Week 9 so Samuel's status is worth monitoring in case the team decides to rest him for a couple of weeks.

49ers WR Deebo Samuel (groin) and RB Trey Sermon (ankle) will not play Week 13 at Seattle.

Related Players: Trenton Cannon, Jeff Wilson, Jauan Jennings, Trent Sherfield

Nothing changes from their expected statuses earlier this week.

49ers coach Kyle Shanahan with following injury updates:

WR Deebo Samuel (groin) -- It's a strain. Expected to miss 1-2 weeks.

Related players: Jauan Jennings, Brandon Aiyuk, Elijah Mitchell, Jeff Wilson

Samuel will miss Week 13, an away game at Seattle, but the team hopes to have him back for Week 14, an early game at Cincy. The good news is owners will have time to adjust lineups if he's a game-time call in Week 14. Samuel had been seeing more work as a runner so Aiyuk and Jennings likely lead the way as receivers while Mitchell and Wilson should eat up Samuel's carries.

Jauan Jennings averaged six offensive snaps over his first seven games. That average has jumped to 30 in the last three. What’s more, it’s clear Jimmy Garoppolo and Kyle Shanahan are gaining trust in him. The 49ers targeted Jennings twice in the deep red zone, and he would have had two touchdowns had his knee hit the ground an inch inside the sideline on the second target. Jennings also was the target on Garoppolo’s first third-down pass — a 21-yard first down — and was worked into the trick play that resulted in a holding penalty on Minnesota’s Patrick Peterson.

Related players: Brandon Aiyuk, Deebo Samuel

Jennings began the season as the team's WR5, but could end up at the team's WR2 assuming Samuel (groin) misses at least Week 13. Even when Samuel returns, Jennings could still have a role as Samuel has been used more as a running back over the last couple of weeks.

49ers WR/offensive weapon Deebo Samuel will have an MRI on his groin today and while he’s expected to miss a little time.

Related players: Brandon Aiyuk, Mohamed Sanu, Jauan Jennings, Jeff Wilson, Elijah Mitchell

The good new is, it’s not considered a major injury, the source said. Samuel was used more as a runner in Week 12 so this may not even create more targets for guys like Aiyuk, Sanu and Jennings. But, it may get Mitchell and Wilson more rushing opportunities. Wilson had just two carries while Mitchell went for 27-133-1 while adding five catches for 33 yards. Owners should probably figure on Samuel missing at least Week 13, with the hope of him returning for Week 14, or at worst, the fantasy playoffs.