Kyle Shanahan says Trey Lance doesn't know when he injured knee. He had 16 carries. Prognosis: NOT a long-term injury, should be 1 to 2 week thing, but possibly just one week.

Jimmy Garoppolo may have better chance to return post-bye for Colts game but all TBD.

It's being called a left knee sprain, according to Inman. The 49ers have a bye in Week 6 and return to play the Colts in Week 7. The bad news is it's a Sunday night game, so owners will need a backup plan if they are counting on Lance or Garoppolo in Week 7. We likely won't know much more until next week.

49ers HC Kyle Shanahan told reporters Friday that Trey Lance will start Week 5 at Arizona.

Related Player: Jimmy Garropolo

This was expected with Jimmy G missing practice this week. Lance is 4for4's #14 QB this week.

As part of a mailbag question, someone asked what the game plan would look like with Trey Lance under center.

I expect it will be a “Back to the Future”-type situation for Kyle Shanahan and Mike McDaniel, who had rookies at quarterback (Robert Griffin III) and running back (Alfred Morris) when they were assistants in Washington in 2012. That team led the NFL in rushing and went to the playoffs. Morris finished with 1,613 rushing yards and Griffin with 815 yards.

Related players: Elijah Mitchell, Trey Sermon, Jimmy Garoppolo

The story said the one big difference is Lance attempted 318 passes at North Dakota State while Griffin attempted 1,192 throws at Baylor, which points more to a run-heavy attack. Anther issue is Sermon has only been OK as a runner over two games, and even if Mitchell returns from a shoulder injury, he's a rookie as well, so there are a lot of questions with the run game. The Niners do have the luxury of a bye in Week 6.

Jimmy Garoppolo "has a chance" to play for 49ers Sunday at Arizona.

Related players: Trey Lance

The tweet went on to say HC Kyle Shanahan said, "It wasn’t as bad as we thought it might have been. Today he’s in a lot of pain and still sore. Wednesday if it’s getter better, he has a good chance." Earlier today there was a report that Garoppolo said the injury felt like someone stepped on his calf. He wasn't able to play in the second half in Week 4, giving way to Lance. Reports earlier today said Garoppolo could miss a couple weeks. The Niners do have a bye in Week 6.

Trey Lance targeted Deebo Samuel on seven of his 18 pass attempts in the second half and both of Samuel’s touchdowns came with Lance at quarterback.

Meanwhile, it was another quiet afternoon for Brandon Aiyuk, who was targeted three times and who had one catch for 15 yards.

The 49ers haven’t had a wide receiver reach 1,000 yards since Anquan Boldin did it in 2014. Samuel is already 49 percent of the way there and is on pace for 2,083 yards. The single-season receiving yards record is 1,964 set by Calvin Johnson in 2012, the story said. The story added through four games, Samuel has gotten 32.3 percent of the 49ers’ targets. Aiyuk has gotten 8.5 percent. With Lance expected to start at least the next game, it's good to know he's looking Samuel's way.

It sounds like QB Jimmy Garoppolo is expecting to miss a couple of weeks with a calf injury.

Related players: Trey Lance

Garoppolo and the 49ers explained the injury as feeling like someone stepped on the back of his calf. These injuries can linger, as Rapoport said. Rapoport added Jimmy G isn't always the same player when battling injuries in his career. So for now, it's Garoppolo to the bench and Lance will start. Of course reports over the last couple of days said the 49ers weren't prepared for Lance to play after taking over for Garoppolo during the second half of Week 4. The good news the staff should have him more prepared heading into Week 5. The Niners play the Cards in Week 5 and have a bye in Week 6.

49ers head coach Kyle Shanahan told reporters Friday that rookie QB Trey Lance should be active Week 1 at the Detroit Lions. Lance has been recovering from surgery to repair a chip in his finger.

Related Player: Jimmy Garoppolo

Shanahanigans for Week 1! A brief reprieve from them was in store with Lance hurt, but now there is the probability that he can get worked in with Week 1 starter Jimmy Garoppolo. It may be best to avoid both Week 1.

49ers QB Jimmy Garoppolo told reporters Wednesday he was starting Week 1 when San Francisco travels to Detroit to take on the Lions.

"Now it's official. I guess," Garoppolo said.

49ers head coach Kyle Shanahan is unsure if Trey Lance (finger) will suit up Week 1.

Jimmy G gets the opportunity to show if he can hold off Lance as the 49ers QB. A road game against the Lions defense helps, but anything less than a complete performance could lead to Garoppolo's removal from the starting job.