Week 4 vs. New England Patriots
The 49ers are riddled with injuries, but Brock Purdy did a nice job keeping the team afloat. Purdy doesn't play defense, so he can't really be blamed for the 49ers' loss last week to the Rams. Purdy may get Deebo Samuel back, though he didn't log a full practice this week. He still has Brandon Aiyuk, Jauan Jennings and George Kittle and faces the league's 28th-ranked passing defense in New England. Purdy is in the mix as a fantasy starter for the week at home.