49ers QB Brock Purdy is active, Bills WR Keon Coleman is inactive for Sunday Night Football.

Purdy was questionable but trended towards playing with a shoulder injury that caused him to miss last week. It will be interesting to see how the 49ers handle him, given the injury and the weather conditions.

Coleman was limited in practice all week with a wrist injury, so it seems the Bills are being cautious with their rookie.

49ers QB Brock Purdy will be listed as questionable for Sunday vs. the Bills, but he fully participated in practice -- a good sign he'll be ready to go.

DE Nick Bosa and LT Trent Williams are out.

Related Players: Brandon Allen, Joshua Dobbs

Good sign for 49ers skill position players, but the Bills present a tough matchup for Purdy without Trent Williams manning the left side. He should remain benched on fantasy lineups in favor of a streamer with a better matchup.

49ers quarterback Brock Purdy did some light throwing without issue Monday, coach Kyle Shanahan said.

Purdy, who missed Sunday’s game with right shoulder soreness, will rest Tuesday.

“We’ll see how it feels on Wednesday,” Shanahan said, via KNBR. “Hopefully, it responds better this week than it did last week with the rest.”

Purdy appeared to injure the shoulder when his hand hit the arm of Seahawks cornerback Devon Witherspoon as he released a pass early in the fourth quarter in Week 11, the story said. The story added the 49ers, though, don’t know specifically when Purdy injured it as he not miss time in that game with the injury.
An MRI showed no damage but after experiencing soreness Purdy got a second MRI last week. The Niners will need Purdy in Week 13 when they travel to the Bills in a Sunday night game. Those counting on Purdy may need to have a backup plan in place this week.

Brock Purdy is NOT practicing as 49ers final session underway in rain before flight to Green Bay.

Related Players: Brandon Allen, Joshua Dobbs

Other 49ers beat reporters had mentioned that Purdy "shut himself down" "mid-practice" on Thursday, which certainly can't be a good sign. All skill position players would take a step down if either Allen or Dobbs ends up playing this weekend, and either would be a QB streaming option for Superflex leagues.

49ers pushing quarterback press conference from today’s usual spot to Friday, reflecting fluid situation with Brock Purdy (shoulder) for Sunday’s game at Green Bay. Could be Brandon Allen out of bullpen.

Related Players: Joshua Dobbs

Other 49ers beat reporters had mentioned that Purdy "shut himself down" "mid-practice", which certainly can't be a good sign. All skill position players would take a step down if either Allen or Dobbs ends up playing this weekend, and either would be a QB streaming option for Superflex leagues.

49ers quarterback Brock Purdy injured his shoulder in the 20-17 loss to the Seahawks on Sunday.

Coach Kyle Shanahan told beat reporters that Purdy is day-to-day with shoulder soreness.

Related players: Brandon Allen, Joshua Dobbs

The 49ers will release their first practice report Wednesday so owners will want to keep a close look as the week progresses. Purdy rushed for 40 yards and a diving touchdown on five carries, and he took two sacks and four additional hits in the pocket, the story pointed out. The Niners play in the later window on Sunday at Green Bay.

Brock Purdy aggravated the stinger injury he initially suffered against the Cardinals in Week 15. But Purdy said after the game that he’s expecting to be fine for the Week 17 game against Washington and head coach Kyle Shanahan reiterated the same on Tuesday.

“Just watching him, how he was that week [after the Cardinals game], and then just being able to hear how he was today and talk to him last night after the game, I think he’s going to be fine,” Shanahan said, via David Bonilla of 49erswebzone.com. “I don’t think it’s going to bother him too [much].

Related players: Sam Darnold

Purdy completed 18-of-32 passes for 255 yards with no touchdowns and four interceptions, working out to a career-worst 42.6 passer rating. In his most extended playing time of the season, Darnold finished the game 8-of-14 for 81 yards with a touchdown and a pick, the story said. The Niners travel to Washington in Week 17.

According to ESPN's Lisa Salters, Brock Purdy has a shoulder stinger and was cleared to return with the 49ers trailing 33-19. The injury against Baltimore is an aggravation of a stinger he suffered in San Francisco's Week 15 win over Arizona.

Related players: Sam Darnold

Darnold took over in the game, but it sounds like entering the game was more about Purdy's performance. One would assume Purdy will get the call in Week 17 as long as he's healthy. The Niners travel to take on the Commanders and it seems like it could be a "get-right" game for Purdy and the 49ers, but be sure to follow the injury reports this week.

49ers quarterback Brock Purdy cleared the NFL’s concussion protocol and will play Sunday against the Bengals.

Purdy was a full participant in practice Friday and now has no official injury designation for the game. There was concern early in the week that Purdy would not be able to go and that Sam Darnold would get the start. But his progress improved over the week, a short one at that, and now Purdy is back. Even with Deebo Samuel still out, Purdy is still a top-10 option for us this week.

49ers QB Brock Purdy (concussion) is present and participating during early open portion of practice.

Related Players: Sam Darnold

Purdy is for sure not still in the clear to start in Week 8, but a Thursday practice swings the probability positively. Players in the confusion protocol have been historically unlikely to play the following week, but it's still in the cards. Friday's practice should give us more insight.