49ers QB Brock Purdy will be listed as questionable for Sunday vs. the Bills, but he fully participated in practice -- a good sign he'll be ready to go.

DE Nick Bosa and LT Trent Williams are out.

Related Players: Brandon Allen, Joshua Dobbs

Good sign for 49ers skill position players, but the Bills present a tough matchup for Purdy without Trent Williams manning the left side. He should remain benched on fantasy lineups in favor of a streamer with a better matchup.

Brock Purdy is NOT practicing as 49ers final session underway in rain before flight to Green Bay.

Related Players: Brandon Allen, Joshua Dobbs

Other 49ers beat reporters had mentioned that Purdy "shut himself down" "mid-practice" on Thursday, which certainly can't be a good sign. All skill position players would take a step down if either Allen or Dobbs ends up playing this weekend, and either would be a QB streaming option for Superflex leagues.

49ers pushing quarterback press conference from today’s usual spot to Friday, reflecting fluid situation with Brock Purdy (shoulder) for Sunday’s game at Green Bay. Could be Brandon Allen out of bullpen.

Related Players: Joshua Dobbs

Other 49ers beat reporters had mentioned that Purdy "shut himself down" "mid-practice", which certainly can't be a good sign. All skill position players would take a step down if either Allen or Dobbs ends up playing this weekend, and either would be a QB streaming option for Superflex leagues.

49ers quarterback Brock Purdy injured his shoulder in the 20-17 loss to the Seahawks on Sunday.

Coach Kyle Shanahan told beat reporters that Purdy is day-to-day with shoulder soreness.

Related players: Brandon Allen, Joshua Dobbs

The 49ers will release their first practice report Wednesday so owners will want to keep a close look as the week progresses. Purdy rushed for 40 yards and a diving touchdown on five carries, and he took two sacks and four additional hits in the pocket, the story pointed out. The Niners play in the later window on Sunday at Green Bay.

Potentially significant: 49ers QB Brock Purdy is in the NFL's concussion protocol, coach Kyle Shanahan tells reporters.

Related Players: Sam Darnold, Brandon Allen

Shanahan has repeatedly gotten the most out of his quarterbacks, making just about anyone that starts a full game at least worth considering. In deep leagues —particularly Superflex Dynasty leagues— it's worth checking if Darnold is sitting on your waiver wires.

Bengals QB Joe Burrow told reporters Wednesday that he will not play Week 18 and will be the backup for Brandon Allen.

Burrow will be the first of many to not play for the Bengals. Joe Mixon (COVID protocols) is also not playing Week 18.