Bills HC Sean McDermott said he thinks RB James Cook and DT Ed Oliver "have a chance" to play against the Titans on Sunday. He says his hope is that both play.

Related players: Ray Davis

Cook was ultimately was ruled out on Monday night in what many felt was a bit of a surprise. Those in the dynasty community have been well aware of Davis and his potential. Davis is considered "old" for a rookie, already 25, but many felt he was NFL-ready, and he showed that on MNF: rushing for 97 and leading the Bills in receiving with a 3-55-0 line. Twice, once after a penalty, Davis was denied a chance for a TD on the 1-yard line and Josh Allen took it in or Davis' fantasy production would have been a few points higher. Still, Davis could have earned himself more work going for forward, but at the very least has fantasy value as a handcuff to Cook owners.

Another Monday night inactive surprise at RB: James Cook is out tonight due to his toe injury, per source. It’s the first NFL game in three seasons that Cook has missed.

Related players: Ray Davis, Ty Johnson, Frank Gore, Jr.

Cook is unable to go tonight. The Bills added to that speculation a few hours ago when they announced rookie RB Gore would suit up. Davis could be in line for the early down work with Johnson getting passing downs. Gore could also mix in as well. It will be a tough matchup against the Jets on the road.

RB James Cook (foot/toe) remained sidelined at Thursday’s Bills practice. Cook’s second straight absence. Looking less likely that he will play against the Jets, but the longer week gives him a better chance.

Related Players: Ray Davis, Ty Johnson

If Cook were to miss Week 6, it's hard to say how the backfield load would get divvied up. Obviously Ty Johnson has more experience than rookie Ray Davis, but it's the latter who leads in the carry department, 26-10. Davis feels like the better pick-up, but neither one would carry a full bellcow load regardless, which makes them iffy spot-starts.

Leonard Fournette tells me he’s in Buffalo and is planning to sign with the Bills today, pending a physical.

Related players: James Cook, Latavius Murray

"Playoff Lenny" had nearly 1,200 all-purpose yards, including a career-high 523 receiving yards, along with 6 TDs last season, Schultz went on to say. Fournette's role in the offense could come in the passing game, an area where Cook has been hit and miss. In Week 8 Cook had just one catch for six yards, but collected three catches for 46 yards and a TD in Week 7. Fournette could also steal some goal line TDs should the Bills opt to go away from Allen in those situations.

Sean McDermott says QB Josh Allen (right shoulder) will "be out there in some capacity at practice today.

RB Damien Harris, TE Quintin Morris and DT Ed Oliver will not practice

Related Players: Latavius Murray, James Cook

It's more likely that Murray continues to take over the early-and-goal-line role than it is that Cook gets a boost in those areas. The Bills have made it clear that they would like to keep the 190-pound running back out of harm's way, as he only has three of the team's 15 rushing attempts from within the opponent's five-yard line. Murray's role should put him in consideration as an RB3 option, as the team is currently 8.5-point favorites against the Patriots.

Sunday night’s game was stopped for several minutes in the first half after Bills running back Damien Harris was injured on a short run.

Harris suffered a neck injury after being hit by Giants linebacker Bobby Okereke and he was loaded on a backboard before being taken off the field by an ambulance.

Related players: James Cook, Latavius Murray, Reggie Gilliam

Harris was able to flash a thumbs up before leaving the field and the Bills announced that he had movement in his arms and legs shortly after the injury.

On one of the first few days, offensive coordinator Ken Dorsey even used the term “three-down back” when speaking about Cook’s potential should he realize it. In practices, Cook continued to provide the team with plenty of reasons to be optimistic about both his outlook and role in their 2023 season. Cook went coast-to-coast as their unquestioned top running back at camp, displaying excellent pass-catching skills and a good knack for finding running lanes between the tackles.

Related Players: Latavius Murray, Damien Harris

Buscaglia continued, "Cook also separated himself from backups Damien Harris and Latavius Murray, with Murray giving Harris a run for the primary backup duties due to his performance."

Cook looks more destined than ever to take a true three-down role, and the upside in this Bills offense would be fantastic, even if his target share is lessened by Josh Allen's legs. Cook is climbing into bona fide RB2 range.

The Bills have signed RB Latavius Murray to a one-year deal.

Related Players: James Cook, Damien Harris, Nyheim Hines

The signing of Murray likely impacts Damien Harris rather than any other back currently on the Bills' depth chart. Harris is also on a one-year "prove-it" deal and operates in essentially the same capacity as Murray has in recent years. In fantasy aspects, Harris and Murray will likely vulture each other's goal-line carries, while Josh Allen will eat into both of their upsides.

James Cook is more than likely the only player we truly want in this backfield as he looks to take a sophomore leap in 2023.

Former Patriots’ RB Damien Harris reached an agreement on a one-year deal with the Buffalo Bills.

Related Players: James Cook

The running back shuffling continues in the AFC, and this one is intra-division. The Bills needed a between-the-tackles banger with only James Cook and Nyheim Hines on the roster, and they got one. Harris had slowly grown out of favor in New England as Rhamondre Stevenson took over a more three-down role. Assuming Buffalo doesn't draft a Day 2 RB, Harris has a chance to replicate his TD-heavy season from 2021.

And another! Colts are trading Nyheim Hines to the Buffalo Bills, sources tell ESPN.

Related players: Devin Singletary, James Cook, Zack Moss, Jonathan Taylor, Deon Jackson

The Bills are adding one of the top pass catching backs to their offense. Hines signed a three-year deal last season so the Bills will have him under control for two more years. It's potentially bad news for Cook owners hoping to see an increase in touches after the Bills bye week. Singletary averaged 10 carries a game and three receptions a game, but Hines will surely cut into that production. Hines was averaging about 3.5 catches a game for the Colts. In Indy, Jackson should move up to the RB2 slot behind Taylor.