49ers QB Nick Mullens will start Sunday, according to Cam Inman of the San Jose Mercury. Jimmy Garoppolo will miss Week 4 with a high ankle sprain.

Mullens will have a nearly-healthy receiving corps and more than capable running backs at his disposal. He is an auto-play in 2QB leagues.

49ers QB Jimmy Garoppolo did not practice Friday with a high ankle sprain, according to David Lombardi of The Athletic.

Related Player: Nick Mullens

Jimmy G missed practice all week, ensuring that he sits out Week 4 against the Giants. Nick Mullens will start again.

49ers quarterback Jimmy Garoppolo still has not returned to practice due to his high-ankle sprain.

Garoppolo missed Week 3 with the injury and the 49ers still managed to stomp the Jets with Nick Mullens at quarterback. It certainly looks like Garoppolo will miss another week, which is not surprising given the nature of his injury. Mullens will fill in under center once again, and he has shown himself to be a serviceable in supporting fantasy production from the San Francisco skill players.

49ers head coach Kyle Shanahan said QB Nick Mullens will start Sunday against the New York Giants, according to Nick Wagoner of ESPN.

Related player: Jimmy Garoppolo

This is not a surprise since Jimmy G is dealing with a high ankle sprain. Mullens is a low-end QB2 on the road in New Jersey.

49ers Head Coach Kyle Shanahan told reporters that starting QB Jimmy Garoppolo will not practice Wednesday.

Garoppolo went down with a significant ankle sprain in Week 2, and it appears backup Nick Mullens is on track to start Week 3 against the Giants. There was optimism yesterday that Garoppolo should be able to return after a short absence, so it will be worth monitoring whether he returns to practice this week. The 49ers offense is likely to adopt an ultra run-heavy approach in Garoppolo's absence, and the offense as a whole is already messy for fantasy due to injuries.