The Cardinals are placing RB James Conner (knee) on injured reserve, per source. He’s out at least four games.

Related players: Keaontay Ingram, Emari Demercado, Corey Clement, Tony Jones

As we reported all this week so far, any missed games from Conner could mean is Demercado Season. Ingram has missed the last couple of contests with his own injury, and when Conner went down last week, Demercado took over the lead role at running back - and even scored a touchdown. He's not necessarily a safe fantasy play, but in deeper leagues you may be able to at least count on his workload. The Cardinals travel to play the Rams which are among the better teams in rushing defense.

Cardinals’ RB James Conner is expected to miss multiple weeks with the knee injury he suffered Sunday vs. the Bengals.

Related players: Keaontay Ingram, Emari Demercado, Corey Clement, Tony Jones

Schefter went on to say Conner is now a candidate to be placed on injured reserve, per sources, which would mean he'll miss at least the next four games. After Conner left the game, Demercado took over the RB duties and will likely do so again with Conner out. Ingram is still dealing with a neck injury and has missed two-straight games and his status is unknown at this point for Week 6. The team did sign Jones but it looks like Demercado could be the RB1 at least in the short term. There's a very good chance Demercado is on your wire outside of deeper and dynasty leagues and could at least make for a usable fill-in at the running back spot.

Cardinals running back James Conner injured his knee in Sunday’s loss to the Bengals, playing only 12 snaps.

“I’m not quite sure yet, but it looks like [Conner could miss] a little bit of time,” Gannon told Arizona Sports on Monday. “We’re still working through that. James will be back at some point but honestly just wanted to add another back for some depth there to make sure we’re OK there for practice and for the games.”

Related players: Tony Jones, Emari Demercado, Keaontay Ingram, Corey Clement

The Cardinals added running back Tony Jones Jr. off waivers from the Saints, a sign Conner could miss time with his injury, the story pointed out. With Ingram (neck) also injured, Demercado replaced Conner and accounted for 57 scrimmage yards and a touchdown on 11 touches. Demercado could again be in line for more work if Conner has to miss time.

RB Marlon Mack is done for the season with an Achilles injury. Brutal injury for a guy who was here a few days.

Related Players: Keaontay Ingram, Corey Clement

Mack had a legitimate shot at earning the RB2 role in Arizona with a depth chart that is severely lacking. While Ingram could see more run in the short term, don't be surprised if the team is back on the hunt for a veteran presence.

Cardinals have informed RB Eno Benjamin - who started for them when James Conner was hurt this season - that they are releasing him.

Related Players: Keaontay Ingram

Benjamin was on the field for exactly one offensive snap in Week 10 after converting his one target in 15 yards the week prior. Rookie sixth-rounder Keaontay Ingram has hardly been used any more than that, but he will operate as the immediate Conner backup for now.

Cardinals’ RB James Conner is out Sunday against the Vikings due to his rib injury.

Related Players: Eno Benjamin, Keaontay Ingram

It looks like Eno Benjamin's backfield yet again, with Keaontay Ingram operating as his backup. Benjamin finished Week 7 as fantasy's RB5.

Running backs James Conner (ribs) and Darrel Williams (knee) were listed as non-participants in practice on Tuesday.

Related players: Eno Benjamin, Keaontay Ingram, Jonathan Ward

Both players were out of practice on Monday and all of last week as well, so getting the green light to play against the Saints on Thursday looks like a long shot. Benjamin started last Sunday and ran 15 times for 37 yards. He’s been listed as limited this week because of a foot injury.

On top of James Conner likely missing this week and likely the next, the Cardinals are also expected to be playing without backup running back Darrel Williams due to a knee injury. Plus, they’ve placed running back Jonathan Ward on injured reserve with a hamstring injury.

Related Players: Eno Benjamin, Keaontay Ingram

The Seahawks' defense has allowed the most yards and second-most touchdowns on the ground while allowing the fifth-highest yards per attempt. Eno Benjamin looks to be operating in the workhorse role while Conner nurses up, which makes him an RB2 play in fantasy this weekend.