49ers RB Christian McCaffrey (oblique/rib), WR Deebo Samuel (shoulder) and LT Trent Williams (ankle) will NOT practice today, per Kyle Shanahan.

No surprise, as Williams and McCaffrey rarely practice on the first day of the week anyway. Tomorrow is a better indicator of progress.

Related Players: Elijah Mitchell, Jordan Mason

Another source following this tweet mentioned that Kyle Shanahan said that McCaffrey's MRI was "encouraging" and he should be considered day-to-day. We have to assume that his workload will at least be cut back if he plays in Week 7, but bench him at your own risk. We will keep an eye on Deebo Samuel's status for Friday's practice.

As I understand it, Christian McCaffrey's injury is more of a pain-tolerance thing. The extra day helps. At this point, it's not out of the question McCaffrey, Deebo Samuel and Trent Williams can all be available.

Related players: Jordan Mason, Elijah Mitchell

The bad news for owners of McCaffrey, and Samuel, is the game is a Monday night contest against the Vikings. Owners of both players will likely need a backup plan in place heading into this week as it's possible both players are game-time calls. According to other reports, McCaffrey's status is a bit more tenuous, as the team is still waiting for more information about McCaffrey, according to ESPN.

49ers head coach Kyle Shanahan gives injury updates on RB Christian McCaffrey (oblique/ribs) and WR Deebo Samuel (shoulder):

CMC is currently having an MRI.

Deebo will be day-to-day.

Related players: Elijah Mitchell, Jordan Mason, Tyrion Davis-Price

Unfortunately, it's not an impactful update... Fantasy owners will be waiting anxiously for further updates on McCaffrey's MRI results. While Samuel is day-to-day, he will be tough to trust even if he plays after he seemed to be a decoy just two weeks ago. If CMC can't go, Mitchell and Mason could split the workload. Mason has been good and scored another touchdown against the Browns with McCaffrey sidelined. It followed a 10-69-1 line on Oct. 8 in mop-up duty against the Cowboys. Mitchell was just back this past week but rushed two times for -3 yards.

Update from the 49ers: Deebo Samuel has a MCL sprain and an ankle sprain and he's expected to return at some point during the regular season.

Related Players: Jordan Mason, Brandon Aiyuk, George Kittle, Jauan Jennings, Ray-Ray McCloud

This is a bummer for the team and fantasy purposes, as this impacts the playoff implications for both facets. If you don't have an IR spot, it may be a waste of a spot for Deebo if he isn't going to return before Week 17.

Christian McCaffrey said he dodged a bullet with his knee issue, said he’ll play in full Sunday. “I feel great,” he said.

Related Players: Tyrion Davis-Price, Jordan Mason

If CMC is a full go, Davis-Price and Mason are obsolete as anything more than a desperation play. McCaffrey should be considered an RB1, even if he's banged up.

Who rises in the running back rotation now that Elijah Mitchell will miss a substantial amount of time? Never underestimate Shanahan’s fondness for veteran Tevin Coleman, who is on the practice squad but had a pivotal role in the Week 5 win in Carolina.

Meanwhile, Shanahan continues to sing the praises of third-round pick Tyrion Davis-Price even though Price has been a healthy scratch since Week 7. Jordan Mason has been in uniform instead of Davis-Price because Mason is the better special-teamer and has become a stalwart on the kickoff and punt units.

Related players: Christian McCaffrey

The story said McCaffrey played about 65% of the snaps but is also dealing with some knee irritation. Ideally, the 49ers would like to keep McCaffrey around that mark, so the RB who is next up could certainly have some fantasy value with Mitchell sidelined again. In deeper leagues or dynasty leagues, Coleman could still be on your wire and may be worth a stash until this situation sorts itself out.

The 49ers hoped to avoid a long-term knee injury with Elijah Mitchell. They didn't. Mitchell is expected to miss 6-8 weeks, per head coach Kyle Shanahan. Meanwhile, the 49ers will manage Christian McCaffrey's "knee irritation" during the week.

Related Players: Jordan Mason, Tyrion Davis-Price

The injury bug continues to live rent-free inside the 49ers backfield. Stay tuned for what exactly "knee irritation" means, but Tyrion Davis-Price should be nabbed off of waiver wires wherever he is available for the fantasy playoffs. Davis-Price is no longer going to be healthy-scratched and needs to be on all fantasy rosters moving forward in case he becomes the de facto RB1 in San Francisco's offense.

Head coach Kyle Shanahan said on Monday that third-round pick Tyrion Davis-Price is going to miss “a few weeks” after suffering a high-ankle sprain in Sunday’s win over the Seahawks.

Related players: Elijah Mitchell, Jeff Wilson, Kyle Juszczyk, Jordan Mason, Marlon Mack

The Niner RBs are falling fast as this comes after the team lost Mitchell for about 8 weeks, according to reports. With Wilson the lead back, Mason now becomes an injury away from possibly seeing a significant fantasy role. Juszczyk could continue to steal goal line TDs.

Rookie running back Tyrion Davis-Price is expected to miss "at least" a few weeks, according to 49ers head coach Kyle Shanahan.

Related Players: Jeff Wilson, Jordan Mason, Marlon Mack

TE Tyler Kroft also has an MCL sprain, to add insult to injury. Jeff Wilson had the majority control of the backfield in Week 2, turning his 20 touches into 103 yards from scrimmage, while Davis-Price and Deebo Samuel had their fair share of work in a lopsided 27-7 victory over the Seahawks. We will keep an eye on the situation as the week(s) progresses, but expect Deebo to continue working as a hybrid back while San Francisco continues to deal with a never-ending barrage of injuries at the position.