Saints TE Taysom Hill (ACL) out for the season

49ers RB Christian McCaffrey went to the locker room with what the team is calling a knee injury.

McCaffrey is questionable to return. McCaffrey took a toss early in the second quarter and went down on his own accord. The team initially said a knee injury but there is concern, though nothing official, that the injury could be his calf or even his Achilles again. Jordan Mason is now handling most of the backfield work while CMC is out.

Edit: McCaffrey may have injured his knee on the previous play before the toss. Him going down on the toss may have been more of him not feeling right when he started running. Either way, it’s an unfortunate setback after he waited quite a long time to finally play this season.

49ers QB Brock Purdy is active, Bills WR Keon Coleman is inactive for Sunday Night Football.

Purdy was questionable but trended towards playing with a shoulder injury that caused him to miss last week. It will be interesting to see how the 49ers handle him, given the injury and the weather conditions.

Coleman was limited in practice all week with a wrist injury, so it seems the Bills are being cautious with their rookie.

Saints TE Taysom Hill was carted off the field with a knee injury, later declared doubtful to return.

The injury occurred in the fourth quarter on a fourth down attempt in which Hill took the snap himself and ran for a first down. Hill had 47 totals yards before the injury, which hopefully isn’t too serious.