49ers WR Deebo Samuel (shoulder) is out for Monday's game against the Vikings and at least another game while RB Christian McCaffrey (oblique) is questionable.

Samuel has a hairline fracture. He will miss at least the next two games against the Vikings and Bengals. The 49ers have their bye in Week 9 so Samuel could potentially return in Week 10 against the Jaguars. McCaffrey, on the other hand, was able to practice in a limited setting Saturday, his first practice of the week. Maybe that's a good sign of him playing, but it feels like a true 50/50. Jordan Mason and Elijah Mitchell are behind McCaffrey. The 49ers will also likely be without star left tackle Trent Williams, as he is listed as doubtful with an ankle injury.

49ers RB Christian McCaffrey (oblique/rib), WR Deebo Samuel (shoulder) and LT Trent Williams (ankle) will NOT practice today, per Kyle Shanahan.

No surprise, as Williams and McCaffrey rarely practice on the first day of the week anyway. Tomorrow is a better indicator of progress.

Related Players: Elijah Mitchell, Jordan Mason

Another source following this tweet mentioned that Kyle Shanahan said that McCaffrey's MRI was "encouraging" and he should be considered day-to-day. We have to assume that his workload will at least be cut back if he plays in Week 7, but bench him at your own risk. We will keep an eye on Deebo Samuel's status for Friday's practice.

None of the injuries to 49ers’ standouts Christian McCaffrey (oblique), Deebo Samuel (shoulder) and Trent Williams (ankle) are considered long-term, per sources. Each has a chance to be ready for Monday night’s game at Minnesota, though the work week will help determine who can play and who can’t.

Of course the bad news for owners is the game is Monday night, so if Samuel and CMC are both game-time decisions, it could leave owners in a bind. Have a backup plan in place.

As I understand it, Christian McCaffrey's injury is more of a pain-tolerance thing. The extra day helps. At this point, it's not out of the question McCaffrey, Deebo Samuel and Trent Williams can all be available.

Related players: Jordan Mason, Elijah Mitchell

The bad news for owners of McCaffrey, and Samuel, is the game is a Monday night contest against the Vikings. Owners of both players will likely need a backup plan in place heading into this week as it's possible both players are game-time calls. According to other reports, McCaffrey's status is a bit more tenuous, as the team is still waiting for more information about McCaffrey, according to ESPN.

49ers head coach Kyle Shanahan gives injury updates on RB Christian McCaffrey (oblique/ribs) and WR Deebo Samuel (shoulder):

CMC is currently having an MRI.

Deebo will be day-to-day.

Related players: Elijah Mitchell, Jordan Mason, Tyrion Davis-Price

Unfortunately, it's not an impactful update... Fantasy owners will be waiting anxiously for further updates on McCaffrey's MRI results. While Samuel is day-to-day, he will be tough to trust even if he plays after he seemed to be a decoy just two weeks ago. If CMC can't go, Mitchell and Mason could split the workload. Mason has been good and scored another touchdown against the Browns with McCaffrey sidelined. It followed a 10-69-1 line on Oct. 8 in mop-up duty against the Cowboys. Mitchell was just back this past week but rushed two times for -3 yards.

NFL Network Insider Ian Rapoport reported Deebo Samuel's X-rays on his shoulder were negative.

This is the life of Samuel owners it seems... After a great performance in Week 3, Samuel looked to be mostly a decoy in Week 4 before somewhat bouncing back in Week 5. But Week 6 was another early exit for Samuel. The good news is Samuel's shoulder injury doesn't appear to be serious which should give him a chance to be back on the field for Week 7. But the Niners don't play until Monday night so owners many want to have a backup plan. Samuel will be tough to trust even if he gets the green light for Week 7.

49ers WR Deebo Samuel has now been ruled out for the remainder of Sunday’s game against the Browns with a shoulder injury.

Samuel was initially deemed questionable to return but now is out for the rest of the game. Samuel wound up with just one target (which was not caught) and 11 rushing yards. The 49ers are in a tight battle with the Browns, whose defense has really held the 49ers in check thus far.

49ers WR Deebo Samuel is questionable to return with a shoulder injury.

Samuel is in the locker room after initially going to the medical tent on the sideline. The 49ers have both him and left tackle Trent Williams questionable to return, certainly a ding to their offense. For now, we could see even more of an uptick for Christian McCaffrey -- who scored a touchdown, surprise, surprise -- and Brandon Aiyuk.

For the Sunday night game, Cowboys standout defender Micah Parson (knee) and 49ers standout offensive weapon Deebo Samuel (knee) will both be at less than 100%.

Related Players: Brandon Aiyuk, George Kittle, Ronnie Bell

As Ian mentions in the video, Samuel did play in Week 4, although it was in an extremely limited role as they sprinkled in a couple of carries. Rapoport expects more for Week 5 but cautions that the team will be careful with his knee injury.