The worst-case scenario might have arrived for the New York Giants.

With four minutes remaining in the fourth quarter, already down three of their top receivers due to injury, Odell Beckham Jr. landed awkwardly after attempting to catch a high slant pass and left the field in a trainer's cart.

Wincing in pain, Beckham covered his face as the cart left the field. The injury was to his left ankle, which was trapped against the ground on the play.

Related players: Sterling Shepard, Brandon Marshall

This didn't look good. ESPN is reporting Beckham is already headed for surgery. NFL Red Zone reported it's a broken fibula. His ankle got pinned and bent under him after getting tackled. The Giants lost their top-three WRs this game so their offense will have some major questions heading into next week. Owners should probably plan on not having Beckham long-term, possibly the rest of the season.

The Giants are down a couple of wide receivers in the second quarter of Sunday’s game against the Chargers.

Sterling Shepard left with a left ankle injury and Brandon Marshall followed with a left ankle injury of his own a couple of plays later. Marshall has been taken back to the locker room on a cart while Shepard remains on the sideline getting attention from the team’s medical staff.

Dwayne Harris also left the game with a foot injury.

Related players: Roger Lewis

The Marshall injury appeared to be much more serious, which at some point could give Shepard perhaps a more significant role if Marshall would have to miss time. However, Shepard was been ruled out for the day as well, as was Harris.

Giants Inactives
Odell Beckham WR
Davis Webb QB
Tavarres King WR
Wayne Gallman RB
Keenan Robinson LB
D.J. Fluker OL
Matt LaCosse TE

Related players: Sterling Shepard

We had a report earlier today that didn't give much of a chance of Beckham being active tonight. As we stated, Shepard should move in and play as the team's WR2 and at least provide a nice fill-in option for Beckham owners.

Odell Beckham will fly with the Giants to Dallas today. After that, expect him to be a game-time decision.

Related Players: Brandon Marshall, Sterling Shepard

It's a good sign that Beckham is at least travelling with the team. So, there's a chance he'll play. However, with the game being Sunday night, fantasy owners need to be ready with a back-up plan if Beckham doesn't play, among players on the Giants, Cowboys, Vikings and Saints. Put Beckham in your flex to also give you options at RB and TE. Some possible last-minute options could be: Cole Beasley, Shane Vereen (PPR), Coby Fleener or Evan Engram.

Giants wideout Odell Beckham left Monday night's game after taking a hard shot directly to his left knee, but did not sustain any serious injuries.

The team's top offensive weapon was drilled by Browns corner Briean Boddy-Calhoun as he came down from nabbing a high pass in the second quarter. Beckham spun his helmet in frustration but walked off the field under his own power. After trotting into the tunnel en route to the locker room, a television camera caught Beckham on his knees rocking back and forth in pain.

ESPN reported during the broadcast that Beckham was being evaluated for both a concussion and an ankle injury, but that Beckham was cleared of any concussion symptoms.

The Giants said officially that Beckham sustained a sprained ankle. X-ray results came back negative and the team says that Beckham will undergo further examination.

In other news, Brandon Marshall underwent an X-ray on his shoulder.

Related players: Sterling Shepard

The Giants will probably put Beckham on ice for the remainder of the preseason, though we should have an idea of how his ankle is progressing based on his practice participation. Given Marshall's apparent shoulder injury, Sterling Shepard might deserve to be bumped up a few spots in the receiver rankings.

Sterling Shepard was looked at on sideline. He's in serious pain. Taken off on cart. Apparently in tears. Not good.

Related players: Odell Beckham, Brandon Marshall, Roger Lewis

Update: Mike Garafolo tweeted, "Early for Giants WR Sterling Shepard but the team is hopeful it's just a bad roll of his ankle. Stay tuned."

Shepard is slated for WR3 duties behind Odell Beckham and Brandon Marshall, but his season may be in jeopardy based on this report. We'll have more details as they emerge. Roger Lewis played the most snaps (24%) of the remaining Giant receivers last year.