According to Staley, wide receiver Mike Williams, safety Nasir Adderley and cornerback Chris Harris Jr. will miss the pivotal game due to being on the reserve/COVID-19 list, per Fernando Ramirez of SI.
Related players: Jalen Guyton, Josh Palmer, Jason Moore
Williams was added to the list on Christmas, and due to the 10-day quarantine rule for unvaccinated players, he will miss Sunday. The NFL recently updated their protocols so that vaccinated players could "test out" of protocols more quickly. Since Adderley and Harris have already been ruled out, it would appear they are unvaccinated as well, according to the story. It's possible Guyton could test out and return. Moore caught three passes for 56 yards in Week 16.