Cardinals RB David Johnson (ankle) practiced in full for the second consecutive day while Chase Edmonds (hamstring) missed a second day of practice this week.

Some positives for Arizona with Johnson inching closer to a return with two straight full practices while Chase Edmonds continues to recover from his hamstring injury. Arizona got a very nice debut from Kenyan Drake against the 49ers in Week 9 and gives them a safety net at the position. Fantasy owners were obviously disappointed in the usage of Johnson when it seemed he was good to go, but all signs are starting to point toward DJ being back in the lineup and ready to roll against the Buccaneers. Drake will likely have an active role as well with Edmonds' status not looking good for Week 10 off the heels of his 100-yard rushing performance against one of the league's best run defenses in San Francisco.

Cardinals RB Chase Edmonds has been ruled out of Thursday’s game against the 49ers with a hamstring injury.

This was the expected move with a short week to prepare. After being acquired by the team on Monday, Kenyan Drake will make his Cardinals debut Thursday night but he faces a stout 49ers defense in his first game with not much time to prepare. And he will be in a timeshare with Alfred Morris. Expectations should be kept somewhat low but Drake did also essentially have another bye week as he was not in Pittsburgh due to the timing of the trade, so he should be fresh. This certainly sounds like a situation to stay clear of, or at the very least, proceed with plenty of caution.

Recently acquired running back Kenyan Drake went through drills Tuesday. He’ll be given a manageable workload Thursday, coach Kliff Kingsbury said.

Related players: David Johnson, Chase Edmonds, Zach Zenner, Alfred Morris

The limited touches will be to help his transition to a new team and a new offense on a short week. It's also a tough matchup against the 49ers. Both Johnson and Edmonds are not expected to play which mean Zenner and Morris could also be involved.

Arizona Cardinals coach Kliff Kingsbury said there's "definitely concern" that running back Chase Edmonds might not play Thursday night against the San Francisco 49ers after leaving Sunday's loss to the New Orleans Saints with a hamstring injury.

Related players: David Johnson, Kenyan Drake, Zach Zenner, Alfred Morris

Edmonds said he's going to try to play but that could be a stretch on a short week. With Drake now in the picture via a trade, it doesn't give him a lot of time either, which means Zenner and Morris could see the bulk of the work. It's not a great matchup for anyone as the Cards take on the 49ers.

Compensation update: Arizona is trading a 2020 6th-round pick that could become a 5th-round pick to Miami in exchange for RB Kenyan Drake, per source.

Related players: David Johnson, Chase Edmonds, Mark Walton, Kalen Ballage

Schefter reported Sunday that Johnson wouldn't be ready for the team's Week 9 game, a short turnaround on Thursday night. With Edmonds (hamstring) now in doubt too, this move makes some sense, but Drake only has three days to get ready in a tough matchup against the 49ers no less. The worst case for Drake owners is he has short term value and Johnson and Edmonds eventually come back. The best case for Drake owners is Johnson's ankle injury is maybe more serious than the team is letting on, and he ends up splitting work with Edmonds, assuming his hamstring injury isn't serious.

Meanwhile in Miami, this seems to open the door for Walton, who had 14 carries last week and looks to be the main back. Ballage could be back on the fantasy radar and did have a TD last week, but only carried three times.