Cardinals WR DeAndre Hopkins (knee) is expected to miss the rest of the regular season. He sprained his knee Week 14 and was expected to get a second opinion Wednesday.

Related Players: Christian Kirk, Zach Ertz, Rondale Moore, A.J. Green

Tough loss for the Cardinals and even tougher for Hopkins now that he is in a stable offense. All pass catchers get a boost without Hopkins.

Kliff Kingsbury said DeAndre Hopkins is having an MRI for a leg injury. No further information.

Kingsbury also said RB James Conner will get an MRI on his ankle.

Related players: A.J. Green, Rondale Moore, Chase Edmonds

Urban's tweet added that Kingsbury said Conner probably has played too many snaps in Edmonds' absence but that Conner has held up to this point. Hopefully for the Cards and for fantasy owners, Conner will be OK for his Week 15 matchup. The good news is the team plays an early Sunday game at Detroit so owners will know Conner's status in advance if he's a game-time call. The team could be close to activating Edmonds as well, as reports said he was close to going in Week 14 against the Rams.

Cardinals HC Kliff Kingsbury told reporters Friday that QB Kyler Murray (ankle) and WR DeAndre Hopkins (hamstring) are game-time decisions Week 13 at Chicago.

Related Players: Colt McCoy, Christian Kirk, Rondale Moore, A.J. Green

With the best record in the NFC, Arizona has wiggle room to be extra cautious with these two. Thankfully, Cardinals-Bears is an early Sunday game so adjustments can be made prior to kick-off.

Arizona Cardinals wide receiver DeAndre Hopkins logged a limited practice on Thursday.

Hopkins has now logged two straight limited practices and is expected to play against the Chicago Bears this weekend. He may see his snaps scaled back in his return to the lineup but maintains WR2 status with obvious WR1 upside. He will likely be listed as questionable heading into the weekend, but fantasy managers should remain optimistic about his availability. Hopkins is currently our 22nd ranked wide receiver for Week 13.

Cardinals QB Kyler Murray (ankle) and WR DeAndre Hopkins (hamstring) are practicing Wednesday, their first since being on bye.

Hopefully the additional week of rest helps get both on the field Week 13. Their matchup against Chicago is exploitable.

Kliff Kingsbury said he remains hopeful that Kyler Murray and DeAndre Hopkins will play Sunday.

The tweet added Kingsbury won't fully say if they will or won't play until he sees them moving around in practice this week. Murray and Hopkins have missed three games and now a Week 12 bye, so the hope is both are ready to go against the Bears in Week 13.

Cardinals WR DeAndre Hopkins (hamstring) will miss Week 11's game at Seattle, while QB Kyler Murray (ankle) will once again be a game-time decision.

Related Player: Colt McCoy

Murray's multiple practice appearances makes him more likely Week 11 than any point the past three weeks. Hopkins is clearly dealing with a more significant hamstring issue.

Cardinals WRs DeAndre Hopkins (hamstring) and Rondale Moore (neck/concussion) are game-time decisions for Week 10 against the Carolina Panthers.

Related Players: Christian Kirk, Andy Isabella, A.J. Green

Hopkins' absence did not matter Week 9, but two straight weeks without him is playing with fire. Moore's injury is tough to predict so plan on playing another receiver.