49ers TE George Kittle (hamstring) is doubtful for Sunday vs. the Rams. WR Deebo Samuel (calf) is out as expected. DE Nick Bosa (rib) is questionable.

Related Players: Eric Saubert, Jake Tonges

This would be yet another blow to a 49ers offense that is reeling. Saubert doesn't need to be started in typical fantasy leagues, and Brock Purdy's fantasy outlook would also take another huge hit.

49ers TE George Kittle was not spotted at practice today and is experiencing tightness in his hamstring, per source. With no practice today, his status for Sunday’s game vs. the Rams is in question.

Related Players: Eric Saubert, Jake Tonges

This would be yet another blow to a 49ers offense that is reeling. Saubert doesn't need to be started in typical fantasy leagues, and Brock Purdy's fantasy outlook would also take another huge hit.

49ers coach Kyle Shanahan told reporters that WR Deebo Samuel has a calf strain and will miss a few weeks. Another star injury for the Niners.

Related players: Brandon Aiyuk, Ricky Pearsall, Jauan Jennings, Ronnie Bell, Chris Conley, Jacob Cowing, George Kittle

It's a big blow to the Niners offense, which is already without Christian McCaffrey for an extended time. There was no mention on whether or not Deebo could end up on IR. Aiyuk should take over as the team's WR1, but who takes over as the WR2 is the bigger question. Kittle is likely next up after Aiyuk, which then leaves Jennings, Bell, Conley and Cowing at WR. Jennings is probably the leading candidate, but probably won't be a safe play in typical leagues. Cowing is a rookie who has stood out over the spring and summer and has been returning kicks, so it's possible he earns a bigger role with Deebo out.

The 49ers are not trading star WR Brandon Aiyuk — he’s staying in SF with a massive extension.

Aiyuk is getting a front-loaded 4-year deal worth $120M. And yes, Aiyuk will now practice.

Related Players: Deebo Samuel, George Kittle, Jauan Jennings

The sweat is over for fantasy managers, and those who grabbed Aiyuk in the 4th are feeling fantastic. The 49ers are set to be an incredible offense once again and Aiyuk should be an easy click in the 3rd round.

49ers TE George Kittle dropped to 214 pounds — a 30-pound loss — after his core muscle surgery (he wasn't able to work out).

Kittle is now fully healthy and back to 240-243 pounds, the rest of the tweet said. Last season, Kittle averaged 5.1 targets per game in 14 games with Deebo Samuel, and saw 18 targets in the two games Samuel missed. In the six games that Samuel has missed over the last two seasons, Kittle has averaged 5.2 receptions for 84 yards and 1.0 touchdown. He’s basically THE fantasy TE1 when Samuel is out and just another TE1 when Samuel is active. Keep in mind that Kittle is entering his age-31 season, though his advanced metrics are still elite.

The 49ers are working to finalize a deal with veteran TE Logan Thomas. After a 55-catch season with the Commanders in 2023, Thomas returns to the NFC West, where he began his career as a QB for the Cardinals.

Related Players: George Kittle, Brayden Willis

This is actually quite an interesting landing spot. Thomas won't have any immediate fantasy upside but would be a streaming option if Kittle were to miss any time.

For a second straight day, 49ers’ WR Deebo Samuel was a full participant at practice and is on track to play Sunday at Jacksonville.

Related Players: Brandon Aiyuk, Ray-Ray McCloud, George Kittle

Looks like the bye week did Samuel some good, and if he's a full participant already, we should expect his normal workload upon his return. He has 397 yards and two all-purpose touchdowns through six games this season, and should be boosted back into WR2 consideration this week.

For the Sunday night game, Cowboys standout defender Micah Parson (knee) and 49ers standout offensive weapon Deebo Samuel (knee) will both be at less than 100%.

Related Players: Brandon Aiyuk, George Kittle, Ronnie Bell

As Ian mentions in the video, Samuel did play in Week 4, although it was in an extremely limited role as they sprinkled in a couple of carries. Rapoport expects more for Week 5 but cautions that the team will be careful with his knee injury.

Update from the 49ers: Deebo Samuel has a MCL sprain and an ankle sprain and he's expected to return at some point during the regular season.

Related Players: Jordan Mason, Brandon Aiyuk, George Kittle, Jauan Jennings, Ray-Ray McCloud

This is a bummer for the team and fantasy purposes, as this impacts the playoff implications for both facets. If you don't have an IR spot, it may be a waste of a spot for Deebo if he isn't going to return before Week 17.

Deebo Samuel (hamstring) was limited for the second straight practice

Related Players: Brandon Aiyuk, George Kittle, Jauan Jennings

If Deebo were to miss, it's possible that there's a little more touchdown equity for the receiving corps as well as Christian McCaffrey and Elijah Mitchell. Samuel hasn't been used as often in the run game as he was in 2021, but he does have two rushing TDs on the season.