RB Isaiah Spiller (ankle) will miss the final preseason game and there is “a chance” he’ll miss the season opener Week 1 against the Raiders, Brandon Staley said.

Related players: Austin Ekeler, Joshua Kelley, Larry Rountree

Kelley, according to several reports, is ahead of everyone in terms of the RB2 role, so this will likely solidify that situation. Ekeler will get a bulk of the work and Rountree could see some snaps as well until Spiller gets back. Spiller could climb into the RB2 role eventually, but for now that will be Kelley.

Joshua Kelley started Saturday’s preseason game against the Rams and had a really efficient game, totaling 44 yards from scrimmage on six touches. In Tuesday’s practice, Kelley continued to get the most first-team work of the three running backs vying for the second running back spot behind Austin Ekeler — Larry Rountree III, rookie Isaiah Spiller and Kelley.

Seems like a bit of an upset fi Kelley comes away with the job, especially with the rookie Spiller garnering a lot of post-NFL Draft hype. Ekeler is ranked fourth on our RB list so he'll get a bulk of the work out of the backfield, especially in the passing game. But the team will have a need for a between-the-tackles-type runner. For Ekeler owners, this is a battle to keep an eye on throughout camp. For the record, the story said the team is happy with Spiller's development to this point.

Austin Ekeler, Larry Rountree and Joshua Kelley all got work at running back with the first-team offense. Isaiah Spiller continues to play primarily with the second and third teams.

Related players: Austin Ekeler, Joshua Kelley, Larry Rountree

The story added Spiller is starting to show the physical play. We have Spiller second on the team's depth chart behind Ekeler, and it's the physical, between the tackles runs that should get him to the point where he's a possible one-two punch with Ekeler.

Isaiah Spiller has been taking reps with the 1st team thus far in training camp, indicating that the RB2 designation is his to lose.

Related Players: Larry Rountree, Joshua Kelley

The Chargers have been unable to find a successful compliment to Austin Ekeler, but that could change in the form of Spiller. The rookie makes for an intriguing late-round pick due to this explosive offense, and his 3,500+ scrimmage yards he accrued throughout college. His current ADP of 13.02 is sure to continue climbing with more positive camp news.

In Popper's post-draft look at the Chargers' depth chart, he notably listed rookie RB Isaiah Spiller ahead of incumbents Larry Rountree III and Joshua Kelley. "Finding a reliable backup behind Ekeler was a priority for general manager Tom Telesco and coach Brandon Staley this offseason, and they think they found that player in Spiller," wrote Popper.

Spiller has similar draft capital than Kelley (4th) and higher capital than Rountree (6th), and is arguably a better pass catcher than both heading into training camp. Spiller appears to be a dynasty player to target should Ekeler get hurt and has later-round value in redraft so long as he does not stumble out the gate.