After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source.

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

Sheesh. We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out.

The 49ers were down to one healthy running back on their active roster, so they added another one off the waiver wire on Tuesday.

The NFL’s daily transaction report shows that they have claimed Israel Abanikanda off of waivers from the Jets. Abanikanda was let go on Monday when the Jets signed running back/kick returner Kene Nwangwu to the 53-man roster.

Christian McCaffrey was officially moved to injured reserve in a corresponding move.

Related players: Isaac Guerendo, Patrick Taylor, Ke'Shawn Vaughn

Guerendo is expected to take over the team's RB1 role with Christian McCaffrey and Jordan Mason both heading to IR. Abanikanda should be a familiar name to those in dynasty circles. He was a 2023 fifth-round pick but at the time was buried on the depth chart with the Jets, and he never earned much of a role on offense and didn’t play in the regular season this year, the story said. He appeared in six games as a rookie and ran 22 times for 70 yards while catching seven passes for 43 yards, the story added. The team also signed Vaughn to their practice squad.

Per Kyle Shanahan, 49ers RB Christian McCaffrey us going back on IR with his PCL injury.

Related players: Isaac Guerendo, Deebo Samuel, Jordan Mason

It’s a 6 week recovery time for CMC, the post went on to say. It's possible he could return if the Niners make a long playoff run, but for this fantasy season, McCaffrey is done. Sandler, in a separate post, mentioned that Mason will also go on IR with a high ankle sprain, leaving Guerendo as the assumed RB1. The Niners will have to make a move to bring in more running backs, but the team did trade up in the fourth round to pick Guerendo, so it's possible they give him a legit chance the rest of the season. He should be a popular pickup off the wire this week.

49ers head coach Kyle Shanahan said after Sunday’s game that running back Christian McCaffrey suffered a potential season-ending PCL injury in his knee.

It’s been that kind of season for the 49ers, who have been decimated by injuries and fell to 5-7 after their 35-10 loss to the now five-time reigning AFC East champion Buffalo Bills. After missing the first eight games of the season with an Achilles injury, McCaffrey finally made his debut in Week 10. He’ll end up playing just four games this season. Not exactly what fantasy owners were hoping for when they spent a high draft pick on him. A vast majority of fantasy leagues saw McCaffrey go No. 1 overall. So it’s back to Jordan Mason, who rushed 13 times for 78 yards, one of the lone bright spots on a night where almost nothing went right offensively for the 49ers. Brock Purdy didn’t even reach 100 yards passing. Overall, it was yet another forgetful night for the reigning NFC champions and it’s the end of the line in 2024 for one of the most exciting running backs in the league.

49ers RB Christian McCaffrey went to the locker room with what the team is calling a knee injury.

McCaffrey is questionable to return. McCaffrey took a toss early in the second quarter and went down on his own accord. The team initially said a knee injury but there is concern, though nothing official, that the injury could be his calf or even his Achilles again. Jordan Mason is now handling most of the backfield work while CMC is out.

Edit: McCaffrey may have injured his knee on the previous play before the toss. Him going down on the toss may have been more of him not feeling right when he started running. Either way, it’s an unfortunate setback after he waited quite a long time to finally play this season.

The 49ers officially activated RB Christian McCaffrey from injured reserve Saturday.

McCaffrey will make his season debut Sunday against the Buccaneers after dealing with Achilles tendinitis since the preseason. McCaffrey isn't quite at the top of the board just yet, but he does slide into the top 10 among running backs this week against a middle-of-the-pack rush defense in Tampa Bay.

49ers RB Christian McCaffrey was limited in practice today, but HC Kyle Shanahan said he has had “no pain”, an encouraging sign for his availability Sunday.

Related Players: Jordan Mason, Kyle Juszczyk, Isaac Guerendo

If the 49ers had a commanding lead in the NFC West, there's a pretty good chance they would be more willing to ease CMC back into the gameplan, but at 4-4, they are not really in a position to mess around here. If McCaffrey is good to go, we should consider him an RB1 in Week 10.

Running back Christian McCaffrey is back on the practice field with the 49ers.

Videos from reporters showed McCaffrey on the field Monday, but any word on his participation level won’t come until Wednesday’s injury report is released.

Head coach Kyle Shanahan said last week that the plan was for McCaffrey, who has missed the entire season with an Achilles injury, to spend the bye week ramping up his work before joining the team at practice this week. That plan did not change and the 49ers officially opened his window to return on Monday, the story went on to say. McCaffrey can practice for the next 21 days before the team would reach a deadline to activate him, but Shanahan indicated that the hope was to have McCaffrey available against the Buccaneers in Week 10 the story added.

49ers plan to open Christian McCaffrey IR window next Monday.

Related players: Jordan Mason

Reports say CMC is really planning to ramp up in order to be back for their Week 10 match at Tampa Bay. The bye week is certainly hitting at the right time and the team will be looking to see if he responds well to this week's hard work to simulate practice, the post added.

Ian Rapoport is reporting the 49ers are still targeting Week 10 for RB Christian McCaffrey's return.

Related players: Jordan Mason, Isaac Guerendo

The Niners have a bye in Week 9 and we reported last week it was looking positive for CMC to return to the field for Week 10, which is an early Sunday game at the Buccaneers. Rapoport has said CMC has been ramping up and so far there have been no setbacks, and that continues to be a target date. It's possible CMC is heavily involved in the pass game with all the injuries to the Niners WRs up to this point.