After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source.

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

Sheesh. We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out.

Running back Elijah Mitchell went on season-ending injured reserve.

Related players: Christian McCaffrey, Jordan Mason, Isaac Guerendo, Matt Breida

Mitchell can only play this season if the 49ers reach an injury settlement with him and waive him from injured reserve, the story said. Mitchell has struggled to stay on the field but when he has played he's certainly impressed. Mason has had a good camp, according to reports and the team has praised his running style so he'll backup CMC. The team traded up to draft Guerendo, so there's a good chance he has a role this season as well.

"Nothing against Elijah Mitchell, but Jordan Mason runs at a very high level." - 49ers HC Kyle Shanahan on Mason earning reps at RB2 when Christian McCaffrey isn't in.

Related players: Isaac Guerendo

Guerendo is going to miss some time at camp and with the rookie out of action, it could mean the RB2 role ends up going to Mitchell or Mason. Mitchell struggles to stay healthy at times, but has excelled in the starting role before. It could just be coach-speak about Mason, but it's also worth paying attention to, especially if you're looking to handcuff McCaffrey this season.

WR Jacob Cowing (hamstring) will likely be out approx 10 days total

RB Isaac Guerendo (hamstring) will be out several weeks.

Related players: Elijah Mitchell, Ricky Pearsall, Jauan Jennings, Jordan Mason

It's always tough for rookies when they miss time in camp. Guerendo was said to be battling for the RB2 spot with the often-injured Mitchell. The Niners traded up to get Guerendo who was having a nice spring. Meanwhile at WR, the team got back Pearsall today but Cowing was trying to work his up with the depth chart as well.

Reigning Offensive Player of the Year Christian McCaffrey once again has reset the RB market, signing a two-year extension with the 49ers, averaging $19 million per year.

McCaffrey will receive an additional $8 million over what he was scheduled to make in the first two years while adding $24 million in guarantees.

Related Players: Elijah Mitchell, Isaac Guerendo, Cody Schrader

McCaffrey solidifies himself on one of the best offenses in the league, and should still be viewed as the best RB option in fantasy football.

49ers RB Christian McCaffrey (oblique) is expected to go tonight.

Related players: Jordan Mason, Elijah Mitchell

This has been the trend since late last week. The Niners should be able to handle the Vikings and their defense, so it's possible if things get out of hand CMC has an early night. But for now, he's expected to go on MNF and should obviously be in lineups. But, there could be a few more carries for Mason and/or Mitchell tonight depending on the flow of the game.

49ers RB Christian McCaffrey (oblique/rib), WR Deebo Samuel (shoulder) and LT Trent Williams (ankle) will NOT practice today, per Kyle Shanahan.

No surprise, as Williams and McCaffrey rarely practice on the first day of the week anyway. Tomorrow is a better indicator of progress.

Related Players: Elijah Mitchell, Jordan Mason

Another source following this tweet mentioned that Kyle Shanahan said that McCaffrey's MRI was "encouraging" and he should be considered day-to-day. We have to assume that his workload will at least be cut back if he plays in Week 7, but bench him at your own risk. We will keep an eye on Deebo Samuel's status for Friday's practice.

As I understand it, Christian McCaffrey's injury is more of a pain-tolerance thing. The extra day helps. At this point, it's not out of the question McCaffrey, Deebo Samuel and Trent Williams can all be available.

Related players: Jordan Mason, Elijah Mitchell

The bad news for owners of McCaffrey, and Samuel, is the game is a Monday night contest against the Vikings. Owners of both players will likely need a backup plan in place heading into this week as it's possible both players are game-time calls. According to other reports, McCaffrey's status is a bit more tenuous, as the team is still waiting for more information about McCaffrey, according to ESPN.

49ers head coach Kyle Shanahan gives injury updates on RB Christian McCaffrey (oblique/ribs) and WR Deebo Samuel (shoulder):

CMC is currently having an MRI.

Deebo will be day-to-day.

Related players: Elijah Mitchell, Jordan Mason, Tyrion Davis-Price

Unfortunately, it's not an impactful update... Fantasy owners will be waiting anxiously for further updates on McCaffrey's MRI results. While Samuel is day-to-day, he will be tough to trust even if he plays after he seemed to be a decoy just two weeks ago. If CMC can't go, Mitchell and Mason could split the workload. Mason has been good and scored another touchdown against the Browns with McCaffrey sidelined. It followed a 10-69-1 line on Oct. 8 in mop-up duty against the Cowboys. Mitchell was just back this past week but rushed two times for -3 yards.