Team news: San Francisco 49ers

Per Kyle Shanahan, 49ers RB Christian McCaffrey us going back on IR with his PCL injury.

Related players: Isaac Guerendo, Deebo Samuel, Jordan Mason

It’s a 6 week recovery time for CMC, the post went on to say. It's possible he could return if the Niners make a long playoff run, but for this fantasy season, McCaffrey is done. Sandler, in a separate post, mentioned that Mason will also go on IR with a high ankle sprain, leaving Guerendo as the assumed RB1. The Niners will have to make a move to bring in more running backs, but the team did trade up in the fourth round to pick Guerendo, so it's possible they give him a legit chance the rest of the season. He should be a popular pickup off the wire this week.

49ers head coach Kyle Shanahan said after Sunday’s game that running back Christian McCaffrey suffered a potential season-ending PCL injury in his knee.

It’s been that kind of season for the 49ers, who have been decimated by injuries and fell to 5-7 after their 35-10 loss to the now five-time reigning AFC East champion Buffalo Bills. After missing the first eight games of the season with an Achilles injury, McCaffrey finally made his debut in Week 10. He’ll end up playing just four games this season. Not exactly what fantasy owners were hoping for when they spent a high draft pick on him. A vast majority of fantasy leagues saw McCaffrey go No. 1 overall. So it’s back to Jordan Mason, who rushed 13 times for 78 yards, one of the lone bright spots on a night where almost nothing went right offensively for the 49ers. Brock Purdy didn’t even reach 100 yards passing. Overall, it was yet another forgetful night for the reigning NFC champions and it’s the end of the line in 2024 for one of the most exciting running backs in the league.

49ers RB Christian McCaffrey went to the locker room with what the team is calling a knee injury.

McCaffrey is questionable to return. McCaffrey took a toss early in the second quarter and went down on his own accord. The team initially said a knee injury but there is concern, though nothing official, that the injury could be his calf or even his Achilles again. Jordan Mason is now handling most of the backfield work while CMC is out.

Edit: McCaffrey may have injured his knee on the previous play before the toss. Him going down on the toss may have been more of him not feeling right when he started running. Either way, it’s an unfortunate setback after he waited quite a long time to finally play this season.

49ers QB Brock Purdy is active, Bills WR Keon Coleman is inactive for Sunday Night Football.

Purdy was questionable but trended towards playing with a shoulder injury that caused him to miss last week. It will be interesting to see how the 49ers handle him, given the injury and the weather conditions.

Coleman was limited in practice all week with a wrist injury, so it seems the Bills are being cautious with their rookie.

49ers QB Brock Purdy will be listed as questionable for Sunday vs. the Bills, but he fully participated in practice -- a good sign he'll be ready to go.

DE Nick Bosa and LT Trent Williams are out.

Related Players: Brandon Allen, Joshua Dobbs

Good sign for 49ers skill position players, but the Bills present a tough matchup for Purdy without Trent Williams manning the left side. He should remain benched on fantasy lineups in favor of a streamer with a better matchup.

49ers quarterback Brock Purdy did some light throwing without issue Monday, coach Kyle Shanahan said.

Purdy, who missed Sunday’s game with right shoulder soreness, will rest Tuesday.

“We’ll see how it feels on Wednesday,” Shanahan said, via KNBR. “Hopefully, it responds better this week than it did last week with the rest.”

Purdy appeared to injure the shoulder when his hand hit the arm of Seahawks cornerback Devon Witherspoon as he released a pass early in the fourth quarter in Week 11, the story said. The story added the 49ers, though, don’t know specifically when Purdy injured it as he not miss time in that game with the injury.
An MRI showed no damage but after experiencing soreness Purdy got a second MRI last week. The Niners will need Purdy in Week 13 when they travel to the Bills in a Sunday night game. Those counting on Purdy may need to have a backup plan in place this week.

Brock Purdy is NOT practicing as 49ers final session underway in rain before flight to Green Bay.

Related Players: Brandon Allen, Joshua Dobbs

Other 49ers beat reporters had mentioned that Purdy "shut himself down" "mid-practice" on Thursday, which certainly can't be a good sign. All skill position players would take a step down if either Allen or Dobbs ends up playing this weekend, and either would be a QB streaming option for Superflex leagues.

49ers pushing quarterback press conference from today’s usual spot to Friday, reflecting fluid situation with Brock Purdy (shoulder) for Sunday’s game at Green Bay. Could be Brandon Allen out of bullpen.

Related Players: Joshua Dobbs

Other 49ers beat reporters had mentioned that Purdy "shut himself down" "mid-practice", which certainly can't be a good sign. All skill position players would take a step down if either Allen or Dobbs ends up playing this weekend, and either would be a QB streaming option for Superflex leagues.

“I will be playing on Sunday. Very excited, can’t pass up playing the Packers. I will be out there for sure.”

George Kittle says he’s good to go for Sunday

Related Players: Eric Saubert

Kittle returns to a great matchup against a Packers defense that ranks 26th in TE aFPA. He should be fired up as a high-end TE1 once again.

Shanahan said George Kittle was “close” to playing against Seattle and should be able to practice Wednesday.

It's at least a good sign Kittle is expected to practice Wednesday. The hope is he will be ready to go in Week 12. The 49ers play at the Packers, and it's in the later Sunday window so owners will certainly want to pay attention to what kind of work Kittle can get in this week at practice.