The 49ers are now considering placing Christian McCaffrey on injured reserve, which would sideline him this week plus three more games, Shanahan said.

Related Players: Jordan Mason, Isaac Guerendo, Patrick Taylor

While it's possible that the team brings in another back, they sure weren't opposed to giving Jordan Mason a phenomenal workload last Monday. As it stands, Mason is a must-rostered, must-start option for as long as McCaffrey is out.

49ers RB Christian McCaffrey (Achilles/calf) feels like a long-shot for Sunday against the Vikings.

Related Players: Jordan Mason, Isaac Guerendo

Jordan Mason went nuclear as a last-minute start in Week 1, so he should be in fantasy lineups of McCaffrey misses again. Guerendo and even Patrick Taylor could be rotated in a little more in Week 2, but aren't worth fantasy stashes quite yet.

San Francisco 49ers head coach Kyle Shanahan pushed back at an earlier ESPN report that star running back Christian McCaffrey could miss Week 2.

When Shanahan was asked about the report from Adam Schefter after the 49ers' 32-19 win on Monday night over the Jets, Shanahan had a quip ready to go.

"That person must've been God," Shanahan said. He added that McCaffrey was a gametime decision on Monday night.

Related players: Jordan Mason

Schefter said McCaffrey pulled out of practice on Friday and no one was overly concerned at the time. But the calf was still tight on Monday before the game when he came in for treatment. However, it's not just his calf, he's also dealing with an Achilles issue. The team made the decision to play it safe since it's a long season and make CMC inactive, Schefter said. Schefter added it's a "strong possibility" McCaffrey won't play in Week 2, at Minnesota on turf. Mason had a huge game taking over for CMC on Monday night against the Jets. It's not necessarily a surprise as the team talked up Mason most of the summer. This is obviously worth monitoring and we can probably expect many different updates for the rest of the week leading up to Week 2. Mason should again be a nice play if CMC can't go. The Niners-Vikings game is also an early game on Sunday so owners will have time to adjust.

The 49ers will have wide receiver Brandon Aiyuk and left tackle Trent Williams against the Jets on Monday night, but they will not have running back Christian McCaffrey.

Jordan Mason, Patrick Taylor and Isaac Guerendo are the available backs for the Niners.

Definitely a shocker and likely a big blow to fantasy owners. According to the story, McCaffrey said on Friday that he had no doubt he would play and there was plenty of optimism from head coach Kyle Shanahan and General Manager John Lynch as well. McCaffrey missed most of the summer with a calf injury and is listed with an Achilles issue as well, the story said. Mason had a great camp and seemed to get a lot of attention from coaches this summer, and likely should get a bulk of the workload tonight against the Jets. Hopefully CMC owners backed themselves up during drafts by nabbing Mason. If Mason is still on your wire, he's worth picking up for any team in case CMC's issues are longer term. Taylor and Guerendo could get work for the Niners as well - if you're in a pinch losing CMC. From the Jets side, Braelon Allen and Israel Abanikanda could see touches behind Breece Hall.

Running back Christian McCaffrey has been sidelined with a calf injury since early in training camp, but Adam Schefter of ESPN reports that he is expected to take part in practice on Tuesday.

Related players: Jordan Mason

As the story said, the team won’t release an injury report detailing his level of participation until Thursday, but his return to the field is a good sign for his availability for the opener. The Niners were probably playing it very safe with who was most likely the number-one pick in your fantasy drafts. And, it's no surprise to see him back to work leading up to the first game of the season. CMC owners should still consider backing him up with Mason if at all possible.

Running back Elijah Mitchell went on season-ending injured reserve.

Related players: Christian McCaffrey, Jordan Mason, Isaac Guerendo, Matt Breida

Mitchell can only play this season if the 49ers reach an injury settlement with him and waive him from injured reserve, the story said. Mitchell has struggled to stay on the field but when he has played he's certainly impressed. Mason has had a good camp, according to reports and the team has praised his running style so he'll backup CMC. The team traded up to draft Guerendo, so there's a good chance he has a role this season as well.

"Nothing against Elijah Mitchell, but Jordan Mason runs at a very high level." - 49ers HC Kyle Shanahan on Mason earning reps at RB2 when Christian McCaffrey isn't in.

Related players: Isaac Guerendo

Guerendo is going to miss some time at camp and with the rookie out of action, it could mean the RB2 role ends up going to Mitchell or Mason. Mitchell struggles to stay healthy at times, but has excelled in the starting role before. It could just be coach-speak about Mason, but it's also worth paying attention to, especially if you're looking to handcuff McCaffrey this season.

WR Jacob Cowing (hamstring) will likely be out approx 10 days total

RB Isaac Guerendo (hamstring) will be out several weeks.

Related players: Elijah Mitchell, Ricky Pearsall, Jauan Jennings, Jordan Mason

It's always tough for rookies when they miss time in camp. Guerendo was said to be battling for the RB2 spot with the often-injured Mitchell. The Niners traded up to get Guerendo who was having a nice spring. Meanwhile at WR, the team got back Pearsall today but Cowing was trying to work his up with the depth chart as well.

49ers DNP: DT Arik Armstead (foot), RB Jordan Mason (hamstring), WR Ray-Ray McCloud (rib), T Trent Williams (resting player)

Eagles DNP: TE Grant Calcaterra (ankle), DT Fletcher Cox (groin), LB Zach Cunningham (hamstring), S Justin Evans (knee), TE Dallas Goedert (forearm)

Related Players: Jack Stoll

It doesn't look like Goedert is trending towards playing in Week 13, so he'll likely miss at least one more week with his forearm injury. Jack Stoll has technically seen an increased workload, but that has parlay into four targets and 17 yards over the last two weeks. Goedert will return to a top-ten TE role when eligible.

49ers RB Christian McCaffrey (oblique) is expected to go tonight.

Related players: Jordan Mason, Elijah Mitchell

This has been the trend since late last week. The Niners should be able to handle the Vikings and their defense, so it's possible if things get out of hand CMC has an early night. But for now, he's expected to go on MNF and should obviously be in lineups. But, there could be a few more carries for Mason and/or Mitchell tonight depending on the flow of the game.